中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase I Study
期刊论文
OAI收割
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 7
作者:
Zhou, Jing
;
Zhang, Hong
;
Ding, Yanhua
;
Wang, Zhen
;
Wang, Yu
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/06/23
hepatic impairment
pharmacokinetics
phosphodiesterase-5 inhibitor
TPN171
A Phase I Study to Evaluate the Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Adults with Renal Impairment
期刊论文
OAI收割
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 8
作者:
Fu, Ping
;
Song, Yi
;
Hu, Chao
;
Yong, Xiaolan
;
Yu, Yang
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/06/23
pharmacokinetics
phosphodiesterase 5 inhibitor
renal impairment
safety
TPN171
Polystyrene microplastics exposure: Disruption of intestinal barrier integrity and hepatic function in infant mice
期刊论文
OAI收割
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2024, 卷号: 288, 页码: 10
作者:
Li, Huan
;
Xu, Shimin
;
Zhou, Feng
;
Liu, Su
;
Zhang, Dong
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2025/04/01
Polystyrene microplastics (PSMPs)
Infant mice
Oral exposure
Intestinal barrier impairment
Hepatic injury
Gut microbiota-brain bile acid axis orchestrates aging-related neuroinflammation and behavior impairment in mice
期刊论文
OAI收割
PHARMACOLOGICAL RESEARCH, 2024, 卷号: 208, 页码: 15
作者:
Ma, Junli
;
Li, Mingxiao
;
Bao, Yiyang
;
Huang, Wenjin
;
He, Xiaofang
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/10/21
aging
brain
neuro-impairment
bile acid
gut microbiota
An fNIRS representation and fNIRS-scales multimodal fusion method for auxiliary diagnosis of amnestic mild cognitive impairment
期刊论文
OAI收割
BIOMEDICAL SIGNAL PROCESSING AND CONTROL, 2024, 卷号: 96, 页码: 12
作者:
Cheng, Shiyu
;
Shang, Pan
;
Zhang, Yingwei
;
Guan, Jianhe
;
Chen, Yiqiang
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/12/06
Mild cognitive impairment
Auxiliary diagnosis
fNIRS
Scales
Multimodal fusion
Scales screening
Memory deficit in patients with cerebral small vessel disease: evidence from eye tracking technology
期刊论文
OAI收割
CEREBRAL CORTEX, 2024, 卷号: 34, 期号: 4
作者:
Huang, Kailing
;
Zhao, Tingting
;
Sun, Weifeng
;
Feng, Li
;
Wang, Quan
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2024/08/14
cerebral small vessel disease
vascular cognitive impairment
eye tracking
memory
attention
PFASs in Cerebrospinal Fluids and Blood-CSF Barrier Permeability in Patients with Cognitive Impairment
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2024, 卷号: 58, 期号: 11, 页码: 5129-5138
作者:
Hong, Xiaowen
;
Tao, Lin
;
Guo, Liyan
;
Luo, Lin
;
Lv, Jia
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/09/12
PFASs
PFOS
cognitive impairment
CSF
blood-CSF barrier
Unlocking the link: how hippocampal glutathione-glutamate coupling predicts cognitive impairment in multiple sclerosis patients
期刊论文
OAI收割
CEREBRAL CORTEX, 2023, 页码: 11
作者:
Li, Fuyan
;
Zong, Wei
;
Xin, Chenxi
;
Ren, Fuxin
;
Li, Ning
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2023/12/11
cognitive impairment
glutamate
glutathione
magnetic resonance spectroscopy
relapsing-remitting multiple sclerosis
Study of the Sine-SSA-BP Model in Classification of Cognitive Impairment by Eye Movement Features for Patients with Epilepsy
会议论文
OAI收割
Hybrid, Chengdu, China, 2023-10-20
作者:
Wei, Xiaojie
;
Zhang, Huangyemin
;
Wen, Shirui
;
Zhu, Guangpu
;
Huang, Kailing
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/08/13
Epilepsy
Cognitive impairment
Eye-tracking
Sine chaotic mapping
Sparrow search algorithm
Back propagation neural network
Prelimbic cortex dynorphin/& kappa; opioid receptor system modulates methamphetamine-induced cognitive impairment
期刊论文
OAI收割
ADDICTION BIOLOGY, 2023, 卷号: 28, 期号: 9, 页码: 12
作者:
Cheng, Ying-jie
;
Deng, Ying-zhi
;
Deng, Di
;
Wu, Man-qing
;
Chai, Jing-rui
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2023/10/17
cognitive impairment
dynorphin
methamphetamine
prelimbic cortex
& kappa
opioid receptor