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Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [50]
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期刊论文 [124]
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Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
A dynamic phosphoproteomic analysis provides insight into the C4 plant maize (Zea mays L.) response to natural diurnal changes
期刊论文
OAI收割
PLANT JOURNAL, 2023, 卷号: 113, 期号: 2, 页码: 291-307
作者:
Gao, Zhi-Fang
;
Yang, Xiu
;
Mei, Yingchang
;
Zhang, Jiao
;
Chao, Qing
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2024/03/07
maize
C4
phosphoproteome
kinase-substrate network
light and temperature
Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance
期刊论文
OAI收割
JOURNAL OF ENDOCRINOLOGY, 2022, 卷号: 254, 期号: 3, 页码: 151-165
作者:
Qin, Wanying
;
Zhang, Ting
;
Ge, Mingxia
;
Zhou, Huimin
;
Xu, Yuhui
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/04/30
RACK1
bile acid
glucose metabolism
insulin sensitivity
ENDOPLASMIC-RETICULUM STRESS
C-KINASE 1
HEPATOCELLULAR-CARCINOMA
STEROL 12-ALPHA-HYDROXYLASE
DOWN-REGULATION
ER STRESS
KAPPA-B
RECEPTOR
ACTIVATION
GROWTH
The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 874474
作者:
Arunachalam, Karuppusamy
;
Sreeja, Puthanpura Sasidharan
;
Yang, Xuefei
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/08/21
reactive oxygen species
oxidative stress
antioxidant
diabetes mellitus
mushroom polysaccharides
AGARICUS-BLAZEI MURILL
GANODERMA-LUCIDUM POLYSACCHARIDES
ACTIVATED SIGNALING PATHWAYS
TYPE-2 DIABETES-MELLITUS
PROTEIN-KINASE-C
MT-ALPHA-GLUCAN
MEDICINAL MUSHROOM
SUBMERGED-CULTURE
PHELLINUS-LINTEUS
STRUCTURAL-CHARACTERIZATION
Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans
期刊论文
OAI收割
CELL CALCIUM, 2021, 卷号: 93, 页码: 102327
作者:
Yang,Zhong-Lin
;
Chen,Jian-Ning
;
Lu,Yu-Yang
;
Lu,Min
;
Wan,Qin-Li
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2022/04/02
Inositol polyphosphates
Inositol polyphosphate multikinase
Type I inositol 5-phosphatase
Development
Calcium signaling
Defecation rhythm
C. elegans
C-ELEGANS
PHOSPHOLIPASE-C
CALCIUM
1,4,5-TRISPHOSPHATE
CALCINEURIN
KINASE
IDENTIFICATION
TRISPHOSPHATE
METABOLISM
RECEPTOR
Non-thermal plasma induces apoptosis accompanied by protective autophagy via activating JNK/Sestrin2 pathway
期刊论文
OAI收割
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2020, 卷号: 53
作者:
Ma, Jie
;
Yu, K. N.
;
Zhang, Hao
;
Nie, Lili
;
Cheng, Cheng
  |  
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2020/10/28
non-thermal plasma
apoptosis
protective autophagy
c-JUN N-terminal kinase
Sestrin2
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Li, Bo-han
;
Zhang, Mei
;
Duan, Ya-nan
;
Shuai, Lin
;
Jiang, Hao-wen
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/21
AMP-activated protein kinase
pyrazolone derivative C29
obesity
energy expenditure
thermogenesis
inguinal white adipose tissue
white adipose browning
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Sun, Shui-mei
;
Xie, Zhi-fu
;
Zhang, Yang-ming
;
Zhang, Xin-wen
;
Zhou, Chen-dong
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/12/24
adenosine 5 '-monophosphate-activated protein kinase
AMPK activator
C24
liver
triglycerides
cholesterol
VLDL
hypolipidemic drug
metabolic syndrome
Synthesis of triazolotriazine derivatives as c-Met inhibitors
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2020, 页码: 8
作者:
Guo, Yuting
;
Peng, Xia
;
Ji, Yinchun
;
Zhang, Yitong
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/12/24
Receptor tyrosine kinase
c-Met
Triazolotriazine
SAR
Cellular potency
Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer
期刊论文
OAI收割
PHYTOMEDICINE, 2019, 卷号: 65, 页码: 11
作者:
Wang Yuwei
;
Tang Chunping
;
Yao Sheng
;
Lai Huanling
;
Li Runze
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer
Natural product
Croton tiglium
Protein kinase C
Molecular modelling