机构

• 上海药物研究所 [28]
• 金属研究所 [7]
• 合肥物质科学研究院 [6]
• 上海神经科学研究所 [5]
• 昆明植物研究所 [4]
• 长春应用化学研究所 [3]
• 更多

采集方式

• OAI收割 [62]
• iSwitch采集 [1]

内容类型

• 期刊论文 [63]

发表日期

• 2025 [1]
• 2024 [1]
• 2021 [7]
• 2020 [2]
• 2019 [2]
• 2018 [6]
• 更多

学科主题

• Biochemist... [2]
• Multidisci... [2]
• Neuroscien... [2]
• Biochemist... [1]
• Biology [1]
• Chemistry [1]
• 更多

筛选

浏览/检索结果: 共63条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   Euphornin L promotes lipid clearance by dual regulation of LDLR and PCSK9 期刊论文  OAI收割 EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021, 卷号: 22, 期号: 6, 页码: 9 作者:  Li, Huihui;  Li, Jun;  Zhang, Xianjing;  Li, Jiaomeng;  Xi, Cong   |  收藏  |  浏览/下载：29/0  |  提交时间：2022/06/15 euphornin L  lipid-lowering activity  low density lipoprotein receptor  proprotein convertase subtilisin  kexin type 9  extracellular signal-regulated kinase protein  secretion   Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu   |  收藏  |  浏览/下载：67/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214 作者:  Xu, Biao;  Wang, Zhi-Peng;  Liu, Qingwang;  Yang, Xiaohong;  Li, Xuemin   |  收藏  |  浏览/下载：25/0  |  提交时间：2021/04/26 Pyruvate dehydrogenase kinase  Proliferation  Cancer metabolism  Structure-activity relationship   Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214, 页码: 16 作者:  Xu, Biao;  Wang, Zhi-Peng;  Liu, Qingwang;  Yang, Xiaohong;  Li, Xuemin   |  收藏  |  浏览/下载：66/0  |  提交时间：2021/05/17 Pyruvate dehydrogenase kinase  Proliferation  Cancer metabolism  Structure-activity relationship   Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794 作者:  Wu, Xiaowei;  Dai, Mengdi;  Cui, Rongrong;  Wang, Yulan;  Li, Chunpu   |  收藏  |  浏览/下载：51/0  |  提交时间：2021/05/24 Tyrosine kinase  Covalent FGFR inhibitors  Virtual screening  Pyrazolo[3,4-d] pyridazinone  Structure-activity relationships  Antitumor efficacy   Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963 作者:  Liu,Jiangxin;  Wu,Xing-De;  Li,Wenyan;  Yuan,Zaifeng;  Yang,Kun   |  收藏  |  浏览/下载：26/0  |  提交时间：2022/04/02 Pseudolaric acid A  Hsp90 inhibitor  Apoptosis  NMR  Structure-activity relationship  Photoaffinity-based probe  Protein-ligand interaction  MOLECULAR CHAPERONE  PROTEIN  TARGET  CANCER  KINASE  NMR  IDENTIFICATION  SELECTIVITY  BINDING  DESIGN   Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer 期刊论文  OAI收割 CANCER CELL INTERNATIONAL, 2021, 卷号: 21, 期号: 1, 页码: 697 作者:  He,YingYing;  He,Zhicheng;  Zhang,Xiaoyu;  Liu,Shubai   |  收藏  |  浏览/下载：56/0  |  提交时间：2022/04/02 Ovarian cancer  Ester lipid  Tyrosine kinase signaling pathway  Platelet-activating factor  FACTOR-ACETYLHYDROLASE ACTIVITY  LYSOPHOSPHATIDIC ACID  FACTOR RECEPTOR  EMERGING ROLE  EXPRESSION  GROWTH  PAF  MECHANISMS  PAFAH1B3  SUBUNIT   DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9 作者:  Dai, Meng-di;  Wang, Yue-liang;  Fan, Jun;  Dai, Yang;  Ji, Yin-chun   |  收藏  |  浏览/下载：86/0  |  提交时间：2021/05/24 receptor tyrosine kinase  FGFR inhibitor  DW14383  antitumor activity