中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [6]
金属研究所 [2]
昆明植物研究所 [1]
合肥物质科学研究院 [1]
采集方式
OAI收割 [10]
内容类型
期刊论文 [10]
发表日期
2025 [1]
2024 [2]
2021 [1]
2020 [1]
2019 [2]
2017 [2]
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学科主题
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题名升序
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Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors
期刊论文
OAI收割
ARCHIV DER PHARMAZIE, 2024, 页码: 16
作者:
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/12/25
inhibitor
pharmacokinetic study
pyridazin-4-one
receptor-interacting protein kinase 1
selectivity
Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 263, 页码: 21
作者:
Zhang, Hongjin
;
Lin, Guohao
;
Jia, Suyun
;
Zhang, Ying
;
Wu, Jianbo
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/01/26
Thieno[3
d ]pyrimidine derivative
Cyclin-dependent kinase 7
Small molecule inhibitor
Kinome selectivity
Triple negative breast cancer
Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963
作者:
Liu,Jiangxin
;
Wu,Xing-De
;
Li,Wenyan
;
Yuan,Zaifeng
;
Yang,Kun
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/04/02
Pseudolaric acid A
Hsp90 inhibitor
Apoptosis
NMR
Structure-activity relationship
Photoaffinity-based probe
Protein-ligand interaction
MOLECULAR CHAPERONE
PROTEIN
TARGET
CANCER
KINASE
NMR
IDENTIFICATION
SELECTIVITY
BINDING
DESIGN
Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10
作者:
Jiang, Zongru
;
Wang, Li
;
Liu, Xuesong
;
Chen, Cheng
;
Wang, Beilei
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2020/11/26
Cancer
VEGFR2 kinase
Kinase inhibitor
Angiogenesis
Inhibitor selectivity
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62
作者:
Tong, Lexian
;
Song, Pinrao
;
Jiang, Kailong
;
Xu, Lei
;
Jin, Tingting
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
CHK1 kinase inhibitor
Selectivity
Monotherapy
Hematologic malignancies
Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and and in vivo study
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 351-368
作者:
Wei, Peng
;
Liu, Bo
;
Wang, Ruifeng
;
Gao, Yinglei
;
Li, Lanlan
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/07/01
Fibroblast growth factor
Tyrosine kinase receptor
Structure-based
Crystallography
Selectivity
Hybrid
5-Hydrosulfonyl-5H- pyrrolo[2.3-b]pyrazine
Inhibitor
Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994
作者:
Qin MingZe
;
Wang Lei
;
Yan Shuang
;
Ma JunJie
;
Tian Ye
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/02/02
TYROSINE KINASE INHIBITOR
LUNG-CANCER
RECEPTOR
T790M
MUTANT
MUTATION
Aminopyrimidines
EGFR T790M/L858R
Selectivity
Anti-resistance
Antiproliferative activity
Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994
作者:
Qin MingZe
;
Wang Lei
;
Yan Shuang
;
Ma JunJie
;
Tian Ye
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2021/02/02
TYROSINE KINASE INHIBITOR
LUNG-CANCER
RECEPTOR
T790M
MUTANT
MUTATION
Aminopyrimidines
EGFR T790M/L858R
Selectivity
Anti-resistance
Antiproliferative activity
O-Linked Triazolotriazines: Potent and Selective c-Met Inhibitors
期刊论文
OAI收割
CHEMMEDCHEM, 2012, 卷号: 7, 期号: 7, 页码: 1276-1285
作者:
Chen, Fang
;
Wang, Ying
;
Ai, Jing
;
Zhan, Zhengsheng
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
c-Met
selectivity
triazolotriazines
tyrosine kinase