中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [5]
上海营养与健康研究所 [2]
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OAI收割 [14]
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期刊论文 [14]
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2024 [3]
2020 [2]
2019 [1]
2017 [1]
2013 [1]
2012 [1]
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Biochemist... [1]
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Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 8
作者:
Zou, Wanyi
;
Li, Mengna
;
Wan, Shili
;
Ma, Jingkun
;
Lian, Linan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/09/26
acute leukemia
MDM2
oxidative phosphorylation
PRMT3
PROTAC
An overview of PROTACs targeting MDM2 as a novel approach for cancer therapy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 8
作者:
Li, Huiwen
;
Cai, Xinhui
;
Yang, Xiaoyu
;
Zhang, Xuan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/09/26
MDM2
PROTAC
p53
MDMX
Targeted protein degradation
Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 270, 页码: 16
作者:
Lin, Zhitong
;
Liu, Chen
;
Yan, Ziqin
;
Cheng, Jing
;
Wang, Xiancheng
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/06/27
MDM2
p53
p21
Imidazolidinone
Apoptosis
Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges
期刊论文
OAI收割
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:
Yu, De-Hua
;
Xu, Zhi-Yuan
;
Mo, Shaowei
;
Yuan, Li
;
Cheng, Xiang-Dong
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/10/26
MDMX
MDM2
p53
oncogene
tumor suppressor
inhibitors
The MDM2/MDMX/p53 axis in the adaptive stress response
期刊论文
OAI收割
TRANSLATIONAL CANCER RESEARCH, 2020, 卷号: 9, 期号: 3, 页码: 1993-1997
作者:
Wang, Bing
;
Rasmussen-Ivey, Cody
;
Little, John B.
;
Yuan, Zhi-Min
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/01/18
The MDM2/MDMX/p53 axis
mild stress
adaptive stress response
cell fate
Prolyl hydroxylase 3 stabilizes the p53 tumor suppressor by inhibiting the p53-MDM2 interaction in a hydroxylase-independent manner
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 25, 页码: 9949-9958
作者:
Xu, Yiming
;
Gao, Qiang
;
Xue, Yaqian
;
Li, Xiuxiu
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/09
p53
protein stability
mouse double minute 2 homolog (MDM2)
cancer stem cells
colon cancer
prolyl hydroxylase 3
Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes
期刊论文
OAI收割
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: -, 页码: 1990
作者:
Li, Shengdi
;
Wang, Zhen
;
Li, Yixue
;
Ding, Guohui
;
Li, Yixue
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/09
p53
protein stability
mouse double minute 2 homolog (MDM2)
cancer stem cells
colon cancer
prolyl hydroxylase 3
Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles
期刊论文
OAI收割
BIOMATERIALS, 2013, 卷号: 34, 期号: 11, 页码: 2738-2747
作者:
Yu, Haijun
;
Zou, Yonglong
;
Jiang, Lei
;
Yin, Qi
;
He, Xinyu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Non-small cell lung cancer
MDM2
pH-responsive
Nanoparticles
siRNA
Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function
期刊论文
OAI收割
international journal of molecular sciences, 2012, 卷号: 13, 期号: 8, 页码: 9709-9740
作者:
Fu, Ting
;
Min, Hanyi
;
Xu, Yong
;
Chen, Jianzhong
;
Li, Guohui
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2013/10/11
p53
MDM2
MDMX
molecular dynamic simulation
conformational change
protein-protein interaction
protein-ligand interaction
A Cell-Based High-Throughput Assay for the Screening of Small-Molecule Inhibitors of p53-MDM2 Interaction
期刊论文
OAI收割
JOURNAL OF BIOMOLECULAR SCREENING, 2011, 卷号: 16, 期号: 4, 页码: 450-456
作者:
Li, Jing
;
Zhang, Shuyong
;
Gao, Linghuan
;
Chen, Ying
;
Xie, Xin
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
p53
MDM2
small-molecule inhibitor
protein-protein interaction
high-throughput screening