中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [8]
水生生物研究所 [5]
上海生物化学与细胞生... [2]
新疆理化技术研究所 [1]
中国科学院大学 [1]
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OAI收割 [16]
iSwitch采集 [1]
内容类型
期刊论文 [17]
发表日期
2023 [1]
2020 [2]
2019 [3]
2018 [2]
2017 [1]
2016 [2]
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学科主题
Biochemist... [3]
Biochemist... [1]
Biology [1]
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浏览/检索结果:
共17条,第1-10条
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Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L
期刊论文
OAI收割
CANCERS, 2023, 卷号: 15, 期号: 21, 页码: 28
作者:
Li, Xin
;
Wu, Xiaowei
;
Nie, Shenyou
;
Zhao, Jidong
;
Yao, Yuan
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/12/19
MLL-rearranged leukemia
super elongation complexes
small-molecule inhibitor
protein-protein interaction
cancer therapeutics
Characterization of functional transposable element enhancers in acute myeloid leukemia
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2020, 卷号: 63, 期号: 5, 页码: 675-687
作者:
Zeng, Yingying
;
Cao, Yaqiang
;
Liu, Denghui
;
Zhang, Xiaoli
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/21
SET ENRICHMENT ANALYSIS
C-JUN
GENE
GENOME
CHROMATIN
EVOLUTION
MLL-AF9
PROTEIN
DNA
DIFFERENTIATION
The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein-Protein Interaction
期刊论文
OAI收割
CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 33, 页码: 5530-5542
作者:
Ye, Xiaoqing
;
Chen, Gang
;
Jin, Jia
;
Zhang, Binzhong
;
Wang, Yinda
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
WDR5
MLL1
histone methyltransferase
small-molecular inhibitor
epigenetics
human acute leukemia
Targeting epigenetic machinery: Emerging novel allosteric inhibitors
期刊论文
OAI收割
PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24
作者:
Ye, Fei
;
Huang, Jing
;
Wang, Hongbo
;
Luo, Cheng
;
Zhao, Kehao
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Epigenetics
PRC2
MLL complex
SWI/SNF
DNMT1
allosteric inhibitors
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 844-847
作者:
Wang, Xiaowen
;
Su, Mingbo
;
Li, You
;
Liu, Tongchao
;
Wang, Yujie
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
LSD1 inhibitor
Tranylcypromine
Menin-MLL1 protei n-protein interaction inhibitor
MV4-11 antiproliferative activity
Structure activity relationship
The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 4, 页码: 638-645
作者:
Ye, Xiaoqing
;
Zhang, Rukang
;
Lian, Fulin
;
Zhang, Weiyao
;
Lu, Wenchao
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
WDR5-MLL1 interaction
Leukemia
Small-molecule
High-throughput screening
Fluorescence polarization (FP)
Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758
作者:
Song, Yakai
;
Li, Linjuan
;
Chen, Yantao
;
Liu, Jingqiu
;
Xiao, Senhao
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2019/01/08
DOT1L
MLL-rearranged leukemia
AlphaLISA
HTS
Novel inhibitors
Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis
期刊论文
OAI收割
CANCER LETTERS, 2018, 卷号: 431, 页码: 150-160
作者:
Zhang, Xiong
;
Zheng, Xingling
;
Yang, Hong
;
Yan, Juan
;
Fu, Xuhong
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/01/08
MLL leukemia
Piribedil
H3K4 methylation
Cell cycle
Apoptosis
Alkaloid constituents from Viola tianschanica
期刊论文
OAI收割
PHYTOCHEMISTRY, 2017, 卷号: 144, 期号: 12, 页码: 233-242
作者:
Chen, QB (Chen, Qi-Bin)
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2018/01/19
Viola Tianshanica
Violaceae
Alkaloids
Menin-mll1 Protein-protein Interaction Inhibitory Effect
Design and synthesis of benzylpiperidine inhibitors targeting the menin-mll1 interface
期刊论文
iSwitch采集
Bioorganic & medicinal chemistry letters, 2016, 卷号: 26, 期号: 18, 页码: 4472-4476
作者:
Ren, Jing
;
Xu, Wei
;
Tang, Le
;
Su, Minbo
;
Chen, Danqi
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/05/09
Menin
Mixed lineage leukemia
Mll1
Sar
Inhibitor