中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [5]
化学研究所 [1]
上海神经科学研究所 [1]
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OAI收割 [7]
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期刊论文 [7]
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2024 [1]
2021 [1]
2019 [2]
2011 [1]
2009 [1]
2008 [1]
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Biochemist... [1]
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The effect of malaria-induced alteration of metabolism on piperaquine disposition in Plasmodium yoelii infected mice and predicted in malaria patients
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2024, 卷号: 64, 期号: 1, 页码: 11
作者:
Xie, Yuewu
;
Zhang, Yifan
;
Lin, Feifei
;
Chen, Xiaoyue
;
Xing, Jie
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/08/22
Malaria
Drug metabolizing enzymes
Piperaquine
Clearance
PBPK modelling
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
OAI收割
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Current trends in drug metabolism and pharmacokinetics
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1113-1144
作者:
Li, Yuhua
;
Meng, Qiang
;
Yang, Mengbi
;
Liu, Dongyang
;
Hou, Xiangyu
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/07/01
Pharmacokinetics
Drug metabolism
Drug-drug interactions
Modeling
Metabolizing enzymes
Transporters
Nuclear receptors
Noncoding RNAs
currenttrendsindrugmetabolismandpharmacokinetics
期刊论文
OAI收割
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1113
作者:
Liu Dongyang
;
Hou Xiangyu
;
Tang Lan
;
Wang Xin
;
Lyu Yuanfeng
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
ARYL-HYDROCARBON RECEPTOR
BLOOD-BRAIN-BARRIER
ORGANIC ANION TRANSPORTERS
CHRONIC KIDNEY-DISEASE
PREGNANE-X-RECEPTOR
P-GLYCOPROTEIN
QUANTITATIVE PREDICTION
CYTOCHROME-P450 ENZYMES
DOWN-REGULATION
IN-VIVO
Pharmacokinetics
Drug metabolism
Drug-drug interactions
Modeling
Metabolizing enzymes
Transporters
Nuclear receptors
Noncoding RNAs
An Examination of the Potential Effect of Lipids on the First-Pass Metabolism of the Lipophilic Drug Anethol Trithione
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 卷号: 100, 期号: 11, 页码: 5048-5058
作者:
Yu, Hong-Zhen
;
Han, Si-Fei
;
Li, Ping
;
Zhu, Chun-Liu
;
Zhang, Xin-Xin
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
anethol trithione
medium chain triglycerides
first-pass metabolism
hepatic metabolism
nonlinear pharmacokinetics
dose proportionality
drug metabolizing enzymes
inhibition
formulation
lipids
Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency
期刊论文
OAI收割
JOURNAL OF NEUROCHEMISTRY, 2009, 卷号: 111, 期号: 2, 页码: 537-546
Zhao, Yanling
;
Pan, Xiaoli
;
Zhao, Jing
;
Wang, Yang
;
Peng, Yun
;
Zhong, Chunjiu
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2012/07/13
hippocampal neurogenesis
pentose-phosphate pathway
thiamine deficiency
transketolase
NONALCOHOLIC WERNICKE ENCEPHALOPATHY
ALPHA-KETOGLUTARATE DEHYDROGENASE
TUMOR-CELL PROLIFERATION
ALZHEIMERS-DISEASE
PYRUVATE-DEHYDROGENASE
METABOLIZING ENZYMES
DEPENDENT ENZYMES
PROGENITOR CELLS
BRAIN
COMPLEX
Function prediction for DNA-/RNA-binding proteins, GPCRs, and drug ADME-associated proteins by SVM
期刊论文
OAI收割
PROTEIN AND PEPTIDE LETTERS, 2008, 卷号: 15, 期号: 5, 页码: 463-468
作者:
Cai, Congzhong
;
Xiao, Hanguang
;
Yuan, Qianfei
;
Liu, Xinghua
;
Wen, Yufeng
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/04/09
Protein Function Prediction
Dna-binding Proteins
Rna-binding Proteins
G-protein Coupled Receptors (Gpcrs)
Drug Absorption Proteins
Drug Metabolizing Enzymes
Drug Distribution And Excretion Proteins
Support Vector Machine (Svm)