中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [22]
大连化学物理研究所 [21]
生态环境研究中心 [3]
中国科学院大学 [2]
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Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active
Identification of HGD and GSTZ1 as Biomarkers Involved Metabolic Reprogramming in Kidney Renal Clear Cell Carcinoma
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 卷号: 23, 期号: 9, 页码: 14
作者:
Wang, Jiyan
;
Chang, Hongkai
;
Su, Meng
;
Qiao, Yaya
;
Sun, Huanran
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2022/08/16
tyrosine metabolism
fumarate
metabolism reprogramming
renal cell carcinoma
Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma
期刊论文
OAI收割
BIOMEDICINES, 2022, 卷号: 10, 期号: 2, 页码: 14
作者:
Wang, Jiyan
;
Qiao, Yaya
;
Sun, Huanran
;
Chang, Hongkai
;
Zhao, Huifang
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/06/15
hepatocellular carcinoma
tyrosine metabolism
lipids synthesis
cell cycle
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
OAI收割
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
Effects of elevated ozone and nitrogen addition on leaf nitrogen metabolism in poplar
期刊论文
OAI收割
JOURNAL OF PLANT ECOLOGY, 2021, 卷号: 14, 期号: 3, 页码: 555-568
作者:
Shang, Bo
;
Feng, Zhaozhong
;
Peng, Jinlong
;
Xu, Yansen
;
Paoletti, Elena
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2021/12/21
enzyme activity
nitrogen addition
nitrogen metabolism
ozone
poplar
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
OAI收割
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
  |  
收藏
  |  
浏览/下载:95/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
Inhibition of phosphatidylinositol kinase-III alpha induces or facilitates lysosome exocytosis from microglia.
期刊论文
OAI收割
NEUROREPORT, 2020, 卷号: 31, 期号: 10, 页码: 697-701
作者:
Mu, Shujing
;
Lim, Nastasia K. -H.
;
Huang, Fude
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/12/24
exocytosis
lysosome
microglia
phosphatidylinositols
Current trends in drug metabolism and pharmacokinetics
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1113-1144
作者:
Li, Yuhua
;
Meng, Qiang
;
Yang, Mengbi
;
Liu, Dongyang
;
Hou, Xiangyu
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
Pharmacokinetics
Drug metabolism
Drug-drug interactions
Modeling
Metabolizing enzymes
Transporters
Nuclear receptors
Noncoding RNAs