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浏览/检索结果: 共13条，第1-10条 帮助

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Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3K alpha inhibitors via virtual screening and docking-based structure optimization 期刊论文  OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 86, 页码: 15
作者:  Gu, Dongyan;  Zhang, Mengmeng;  Cai, Lvtao;  Wang, Chang;  Zhou, Yu -Bo
  |  收藏  |  浏览/下载：19/0  |  提交时间：2023/10/17
Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3K alpha inhibitors in oesophageal squamous cell carcinoma 期刊论文  OAI收割
CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 卷号: 12, 期号: 5, 页码: 17
作者:  
  |  收藏  |  浏览/下载：54/0  |  提交时间：2022/08/16
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening 期刊论文  OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 9
作者:  Gu, Dongyan;  Cheng, Gang;  Zhang, Mengmeng;  Zhou, Yu-Bo;  Li, Jia
  |  收藏  |  浏览/下载：28/0  |  提交时间：2021/05/24
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors 期刊论文  OAI收割
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Wang, Yi;  Song, Kun
  |  收藏  |  浏览/下载：47/0  |  提交时间：2020/07/01
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA(H1047R) accompanied with pro-tumorigenic secretome 期刊论文  OAI收割
INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 3, 页码: 817-829
作者:  Liu, Xue-Ling;  Liu, Jia-Li;  Xu, Yi-Chao
  |  收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01
Simultaneous inhibition of PI3K alpha and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer 期刊论文  OAI收割
CANCER BIOLOGY & MEDICINE, 2019, 卷号: 16, 期号: 1, 页码: 66-+
作者:  Wang, Yuxiang;  Li, Xian;  Liu, Xueling;  Chen, Yi;  Yang, Chunhao
  |  收藏  |  浏览/下载：30/0  |  提交时间：2020/07/01
PI3K alpha  CDK4/6  KRAS  NSCLC  CYH33  
Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer 期刊论文  OAI收割
CANCER BIOLOGY & MEDICINE, 2019, 卷号: 16, 期号: 1, 页码: 66-83
作者:  Wang, Yuxiang;  Li, Xian;  Liu, Xueling;  Chen, Yi;  Yang, Chunhao
  |  收藏  |  浏览/下载：21/0  |  提交时间：2024/03/21
PI3K alpha  CDK4/6  KRAS  NSCLC  CYH33  
PI3K alpha inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment 期刊论文  OAI收割
CANCER LETTERS, 2019, 卷号: 459, 页码: 145-155
作者:  Shi, Jia-jie;  Xing, Hui;  Wang, Yu-xiang;  Zhang, Xi;  Zhan, Qi-min
  |  收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822
作者:  Wang, Jia;  Gong, Grace Qun;  Zhou, Yan;  Lee, Woo-Jeong;  Buchanan, Christina Maree
  |  收藏  |  浏览/下载：97/0  |  提交时间：2019/01/08
The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide 期刊论文  OAI收割
CARBOHYDRATE POLYMERS, 2017, 卷号: 174, 页码: 1138-1143
作者:  
收藏  |  浏览/下载：85/0  |  提交时间：2017/12/19