机构

• 上海药物研究所 [13]
• 生物物理研究所 [1]
• 水生生物研究所 [1]

采集方式

• OAI收割 [15]

内容类型

• 期刊论文 [14]
• 会议论文 [1]

发表日期

• 2024 [2]
• 2023 [2]
• 2022 [1]
• 2019 [4]
• 2018 [4]
• 2016 [1]
• 更多

学科主题

• Cell Biolo... [1]

筛选

浏览/检索结果: 共15条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism 期刊论文  OAI收割 LIVER INTERNATIONAL, 2024, 页码: 17 作者:  Hou, Aijun;  Xu, Xiaoding;  Zhang, Yu;  He, Hongxiu;  Feng, Yihan   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/05/07 Drosha degradation  lipid metabolism  miRNA biogenesis  NAFLD  PRMT5   Structure-based discovery of a new series of nucleoside-derived ring-opening PRMT5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 267, 页码: 19 作者:  Chen, Yuting;  Wang, Zekun;  Zhang, Junjie;  Shi, Qiongyu;  Yang, Hong   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/05/07 PRMT5  Nucleoside derivatives  Methyltransferases  Structure -activity relationship   A patent review of PRMT5 inhibitors to treat cancer (2018-present) 期刊论文  OAI收割 EXPERT OPINION ON THERAPEUTIC PATENTS, 2023, 页码: 28 作者:  Gao, Jing;  Yang, Jie;  Xue, Shengyu;  Ding, Hong;  Lin, Hua   |  收藏  |  浏览/下载：18/0  |  提交时间：2023/10/17 PRMT5  inhibitor  epigenetic target  cancer treatment  combined treatment   Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 20 作者:  Chen, Yuting;  Shi, Qiongyu;  Yang, Hong;  Li, Jiayi;  Zhou, Kaixin   |  收藏  |  浏览/下载：33/0  |  提交时间：2023/04/10 Epigenetic  PRMT5 inhibitor  Nucleoside derivatives  Structure-activity Relationship Prodrug   Identification of PRMT5 inhibitors with novel scaffold structures through virtual screening and biological evaluations 期刊论文  OAI收割 JOURNAL OF MOLECULAR MODELING, 2022, 卷号: 28, 期号: 7, 页码: 184 作者:  Zhang, Qian;  Zhang, Lun;  Jin, Jia;  Fan, Yaohua;  Wang, Xiaoguang   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/03/21 PRMT5  Small-molecule inhibitors  Virtual screening  Molecular docking  Molecular dynamics simulations   Zebrafish prmt5 arginine methyltransferase is essential for germ cell development 期刊论文  OAI收割 DEVELOPMENT, 2019, 卷号: 146, 期号: 20, 页码: 16 作者:  Zhu, Junji;  Zhang, Dawei;  Liu, Xing;  Yu, Guangqing;  Cai, Xiaolian   |  收藏  |  浏览/下载：38/0  |  提交时间：2020/05/08 Germ cell  Prmt5  Zebrafish  Zili  Ziwi  Vasa   Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity 期刊论文  OAI收割 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 8, 页码: 775-785 作者:  Zhu, Kongkai;  Shao, Jingwei;  Tao, Hongrui;  Yan, Xue;  Luo, Cheng   |  收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 PRMT5 inhibitor  Anti-proliferative  Cellular target validation  Design and synthesis   Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 317-333 作者:  Shao, Jingwei;  Zhu, Kongkai;  Du, Daohai;  Zhang, Yuanyuan;  Tao, Hongrui   |  收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 PRMT5 inhibitors  N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives  Anti-tumor   Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4 alpha 期刊论文  OAI收割 THERANOSTICS, 2019, 卷号: 9, 期号: 9, 页码: 2606-2617 作者:  Zheng, Bai-Nan;  Ding, Chen-Hong;  Chen, Shi-Jie;  Zhu, Kongkai;  Shao, Jingwei   |  收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01 PRMT5  HNF4 alpha  hepatocellular carcinoma  cancer stem cells   Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi   |  收藏  |  浏览/下载：111/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation