机构

• 上海药物研究所 [7]

采集方式

• OAI收割 [7]

内容类型

• 期刊论文 [7]

发表日期

• 2023 [2]
• 2019 [1]
• 2018 [4]

学科主题

筛选

浏览/检索结果: 共7条，第1-7条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 A patent review of PRMT5 inhibitors to treat cancer (2018-present) 期刊论文  OAI收割 EXPERT OPINION ON THERAPEUTIC PATENTS, 2023, 页码: 28 作者:  Gao, Jing;  Yang, Jie   |  收藏  |  浏览/下载：18/0  |  提交时间：2023/10/17 PRMT5  inhibitor  epigenetic target  cancer treatment  combined treatment   Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 20 作者:  Chen, Yuting;  Shi, Qiongyu;  Yang, Hong;  Li, Jiayi;  Zhou, Kaixin   |  收藏  |  浏览/下载：42/0  |  提交时间：2023/04/10 Epigenetic  PRMT5 inhibitor  Nucleoside derivatives  Structure-activity Relationship Prodrug   Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity 期刊论文  OAI收割 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 8, 页码: 775-785 作者:  Zhu, Kongkai;  Shao, Jingwei;  Tao, Hongrui;  Yan, Xue;  Luo, Cheng   |  收藏  |  浏览/下载：32/0  |  提交时间：2020/07/01 PRMT5 inhibitor  Anti-proliferative  Cellular target validation  Design and synthesis   Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li   |  收藏  |  浏览/下载：118/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan   |  收藏  |  浏览/下载：137/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 9, 页码: 1476-1483 作者:  Zhu, Kongkai   |  收藏  |  浏览/下载：70/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Resynthesis  Virtual screening  Molecular docking  Molecular dynamics simulation   Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods 期刊论文  OAI收割 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 495, 期号: 1, 页码: 721-727 作者:  Zhu, Kongkai;  Jiang, Cheng-Shi;  Hu, Junchi;  Liu, Xigong   |  收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 PRMT5 SAM competitive inhibitor  Molecular docking  Molecular dynamics simulation  Molecular mechanics/Poisson-Boltzmann surface area  PRMT5:MEP50 interaction