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浏览/检索结果: 共529条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序作者升序作者降序 Bioactivity-based molecular networking-guided identification of methyl rosmarinate from Orthosiphon aristatus as a PTP1B inhibitor that improves insulin sensitivity in diabetic mice 期刊论文  OAI收割 PHYTOMEDICINE, 2025, 卷号: 148, 页码: 14 作者:  Xie, Bojun;  Zhu, Dafu;  Li, Linxuan;  Lou, Ruohan;  Wang, Rui   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/12/04 Type 2 diabetes  Bioactivity-based molecular networking  Protein tyrosine phosphatase 1B  Orthosiphon aristatus  Methyl rosmarinate  Insulin sensitivity   PHLPP1 deficiency alleviates dopaminergic neurodegeneration and represses neuroinflammation in Parkinson's disease 期刊论文  OAI收割 BEHAVIORAL AND BRAIN FUNCTIONS, 2025, 卷号: 21, 期号: 1, 页码: 12 作者:  Chen, Zhilin;  Liu, Yuan;  Zhao, Jinyue;  Zhou, Xin;  Han, Yudi   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/12/04 Pleckstrin homology domain leucine-rich repeat protein phosphatases (PHLPP)  Parkinson's disease  Neuroinflammation  NLRP3  Caspase1, IL-1 beta  Proinflammatory cytokines  Anti-inflammatory cytokines   GLS1-RNA Polymerase II Axis Mediates Glutamine-Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High-Protein Diets 期刊论文  OAI收割 ADVANCED SCIENCE, 2025, 页码: 16 作者:  Wu, Wenbiao;  Jiang, Haowen;  Liu, Yichang;  Peng, Chang;  Wang, Hanlin   |  收藏  |  浏览/下载：8/0  |  提交时间：2025/12/04 alcoholic fatty liver disease  GLS1  hepatic lipogenesis  high-protein diets  RNA polymerase II   First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy-lysosome pathway 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 5, 页码: 2612-2624 作者:  Zhong, Ye;  Xu, Jing;  Cao, Huiying;  Gao, Jie;  Ding, Shaoyue   |  收藏  |  浏览/下载：48/0  |  提交时间：2025/07/25 Protein degradation  Hydrophobic tags  ATG101  Autophagy-lysosome pathway  CDK9  Cyclin T1  Degrader  Antitumor   Adaptor protein complex 1 facilitates ciliary localization of serotonin receptor type 6 期刊论文  OAI收割 CELLULAR SIGNALLING, 2025, 卷号: 135 作者:  Qin, Yuanyuan;  Miyoshi, Ko;  Yinsheng, Zhuoma;  Fujiwara, Yuuki;  Yoshimura, Takeshi   |  收藏  |  浏览/下载：12/0  |  提交时间：2025/11/27 AP-1  gamma 1-Adaptin  Primary cilia  Serotonin receptor type 6  G protein-coupled receptors   Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13 作者:  Tang, Mingze;  Zhou, Xuan;  Shen, Qianqian;  Fang, Chen;  Peng, Xia   |  收藏  |  浏览/下载：54/0  |  提交时间：2024/08/22 Receptor -interacting protein kinase 1  Histone deacetylases  Inhibitor  Molecular dynamics (MD) simulation  ADMET analysis   Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors 期刊论文  OAI收割 ARCHIV DER PHARMAZIE, 2024, 页码: 16 作者:  An, Yuxiang;  Peng, Xia;  Wang, Tianchen;  Liu, Kaiyuan;  Feng, Dazhi   |  收藏  |  浏览/下载：53/0  |  提交时间：2024/12/25 inhibitor  pharmacokinetic study  pyridazin-4-one  receptor-interacting protein kinase 1  selectivity   Discovery and optimization of 3-(indolin-5-yloxy)pyridin-2-amine derivatives as potent necroptosis inhibitors 期刊论文  OAI收割 ARCHIV DER PHARMAZIE, 2024, 页码: 21 作者:  Lan, Yaohan;  Ji, Yinchun;  Peng, Xia;  Duan, Wenhu;  Geng, Meiyu   |  收藏  |  浏览/下载：37/0  |  提交时间：2024/08/22 autoimmune disease  necroptosis inhibitor  pharmacokinetic profile  receptor interacting protein kinase 1 (RIPK1)  structural optimization   New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9 作者:  Zheng, Yingying;  Lu, Li;  Li, Mengyue;  Xu, Dehua;  Zhang, Laishun   |  收藏  |  浏览/下载：101/0  |  提交时间：2024/01/26 Chromone  Thiazolidine-2  4-dione  Protein tyrosine phosphatase 1B  Inhibitors   Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study 期刊论文  OAI收割 JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12 作者:  Zhao, Tian-Tian;  Hu, Hao-Jie;  Gao, Li-Xin;  Zhou, Yu-Bo;  Zhu, Yun-Long   |  收藏  |  浏览/下载：78/0  |  提交时间：2023/10/17 Protein tyrosine phosphatases inhibitors  PTP1B inhibitors  Mechanism study  Molecular dynamics