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浏览/检索结果: 共46条，第1-10条 帮助

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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia
  |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07
Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study 期刊论文  OAI收割
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12
作者:  Zhao, Tian-Tian;  Hu, Hao-Jie;  Gao, Li-Xin;  Zhou, Yu-Bo;  Zhu, Yun-Long
  |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17
SH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade 期刊论文  OAI收割
ARTHRITIS & RHEUMATOLOGY, 2022, 页码: 12
作者:  Liu, Qianqian;  Zhai, Linhui;  Han, Mingrui;  Shi, Dongquan;  Sun, Ziying
  |  收藏  |  浏览/下载：27/0  |  提交时间：2022/06/15
Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020) 期刊论文  OAI收割
CURRENT MEDICINAL CHEMISTRY, 2021, 卷号: 28, 期号: 19, 页码: 3825-3842
作者:  Wu, Jingwei;  Zhang, Huan;  Zhao, Guilong;  Wang, Runling
  |  收藏  |  浏览/下载：15/0  |  提交时间：2021/08/17
Synthesis and PTP1B/TCPTP Inhibitory Activity Evaluation of Novel 2,5-Disubstituted-1,3,4-thiadiazolamide Derivatives Containing Carbazole/Benzimidazole Moity 期刊论文  OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 39, 期号: 9, 页码: 2599-2608
作者:  Li Yingjun;  Zhao Yue;  Jin Kun;  Gao Lixin;  Sheng Li
  |  收藏  |  浏览/下载：22/0  |  提交时间：2020/07/01
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 178-185
作者:  Li, Xiangqian;  Xu, Qi;  Li, Chao;  Luo, Jiao;  Li, Xiuxue
  |  收藏  |  浏览/下载：59/0  |  提交时间：2019/05/15
Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 136, 页码: 348-359
作者:  Li, Xiang-Qian;  Xu, Qi;  Luo, Jiao;  Wang, Li-Jun;  Jiang, Bo
  |  收藏  |  浏览/下载：24/0  |  提交时间：2017/10/09
Synthesis and biological evaluation of novel 2,3-pyrazole ring-substituted-4,4-dimethyl lithocholic acid derivatives as selective protein tyrosine phosphatase 1B (PTP1B) inhibitors with cellular efficacy 期刊论文  OAI收割
RSC ADVANCES, 2015, 卷号: 5, 期号: 129, 页码: 106551-106560
作者:  Mao, Shi-Wei;  Shuai, Lin;  He, Hai-Bing;  Pan, Na;  Gao, Li-Xin
  |  收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08
Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors 期刊论文  OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 8, 页码: 1889-1894
作者:  Wang, Wen-Long;  Huang, Chao;  Gao, Li-Xin;  Tang, Chun-Lan;  Wang, Jun-Qing
  |  收藏  |  浏览/下载：9/0  |  提交时间：2019/01/08
Sarsolenane and Capnosane Diterpenes from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller as PTP1B Inhibitors 期刊论文  OAI收割
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 卷号: 2014, 期号: 9, 页码: 1841-1847
作者:  Liang, Lin-Fu;  Kurtan, Tibor;  Mandi, Attila;  Gao, Li-Xin;  Li, Jia
  |  收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08