中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [38]
大连化学物理研究所 [3]
过程工程研究所 [3]
金属研究所 [2]
西北高原生物研究所 [2]
生态环境研究中心 [2]
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OAI收割 [52]
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期刊论文 [51]
会议论文 [1]
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2024 [5]
2023 [3]
2022 [4]
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2020 [3]
2019 [3]
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Pharmacolo... [3]
Chemistry [2]
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Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors
期刊论文
OAI收割
ARCHIV DER PHARMAZIE, 2024, 页码: 16
作者:
An, Yuxiang
;
Peng, Xia
;
Wang, Tianchen
;
Liu, Kaiyuan
;
Feng, Dazhi
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/12/25
inhibitor
pharmacokinetic study
pyridazin-4-one
receptor-interacting protein kinase 1
selectivity
Prediction of Multi-Pharmacokinetics Property in Multi-Species: Bayesian Neural Network Stacking Model with Uncertainty
期刊论文
OAI收割
MOLECULAR PHARMACEUTICS, 2024, 页码: 16
作者:
Zhang, Yuanyuan
;
Xie, Zhiyin
;
Xiao, Fu
;
Yu, Jie
;
Fan, Zhehuan
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/12/11
pharmacokinetic parameters
machine learning
uncertainty
stacking
multitask learning
ADME
Strap-on Buoyant Device to Enhance Gastrointestinal Tract Retention of Felodipine Osmotic Pump Tablets
期刊论文
OAI收割
AAPS PHARMSCITECH, 2024, 卷号: 25, 期号: 8, 页码: 14
作者:
Ni, Qijia
;
Li, Zeru
;
Baqing, Libumo
;
Li, Tianfu
;
Xu, Huipeng
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/12/11
Gastro-retentive floating device
Osmotic pump
Pharmacokinetic
Stereolithography three-dimensional printing
Discovery and optimization of 3-(indolin-5-yloxy)pyridin-2-amine derivatives as potent necroptosis inhibitors
期刊论文
OAI收割
ARCHIV DER PHARMAZIE, 2024, 页码: 21
作者:
Lan, Yaohan
;
Ji, Yinchun
;
Peng, Xia
;
Duan, Wenhu
;
Geng, Meiyu
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/08/22
autoimmune disease
necroptosis inhibitor
pharmacokinetic profile
receptor interacting protein kinase 1 (RIPK1)
structural optimization
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 16
作者:
Cheng, Chen
;
Ren, Chao
;
Li, Mu-zi
;
Liu, Yi-hui
;
Yao, Ren-qi
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/02/27
Traditional Chinese medicine
XueBiJing
sepsis
mortality
pharmacokinetic compatibility
polypharmacology
Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 13
作者:
Yang, Hanxi
;
You, Mengyuan
;
Shu, Xiaoyang
;
Zhen, Jingyao
;
Zhu, Mengwei
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/17
Peptidomimetics
Benzothiazolyl ketone
3CLpro inhibitor
Pharmacokinetic properties
SARS-CoV-2
Synthesis, cytotoxicity, and pharmacokinetic evaluations of niclosamide analogs for anti-SARS-CoV-2
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 253, 页码: 11
作者:
Li, Rui
;
Zhang, Zherui
;
Huang, Shuhong
;
Peng, Ke
;
Jiang, Hualiang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/10/17
SARS-CoV-2
Niclosamide analogs
Cytotoxicity
Pharmacokinetic
SKP2 inhibition
Simultaneous quantification of 3 ',4 '-dimethoxy flavonol-3-O-glucoside and its major metabolite in human plasma by LC-MS/MS and its application to a clinical pharmacokinetic study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 225, 页码: 9
作者:
Wang, Lu
;
Shen, Haifeng
;
Zhan, Yan
;
Zhang, Yifan
;
Zhang, Yong
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2023/04/10
3?4?-Dimethoxy flavonol-3-O-glucoside
Aglycone glucuronide
LC-MS
MS
Human pharmacokinetic study
Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1537-1555
作者:
Li, Ennian
;
Wang, Kai
;
Zhang, Bei
;
Guo, Siqi
;
Xiao, Senhao
  |  
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2022/08/16
DNMT1 inhibitor
A549 cell lines
HCT116 cell lines
antitumor activity
pharmacokinetic
Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 12, 页码: 3080-3095
作者:
Li, Chuan
;
Jia, Wei-wei
;
Yang, Jun-ling
;
Cheng, Chen
;
Olaleye, Olajide E.
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/03/21
Chinese herbal medicine
pharmacokinetics
multi-compound pharmacokinetic research
drug-combination pharmacokinetic research
pharmacokinetic compatibility