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浏览/检索结果: 共644条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Structural analogs modulate olfactory and behavioral responses to a bile acid sex pheromone in sea lamprey (Petromyzon marinus) 期刊论文  OAI收割 JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 2025, 页码: 13 作者:  Scott, Anne M.;  Li, Ke;  Riedy, Joseph J.;  Li, Weiming   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/11/03 Olfaction  Electrophysiology  Structure-activity relationships  Sensory ecology  Chemoreception  Behavioral antagonist   Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24 作者:  Li, Na;  Wang, Linlin;  Hu, Xinyuan;  Xu, Haiyan;  Yang, Bowen   |  收藏  |  浏览/下载：5/0  |  提交时间：2025/08/20 Voltage-gated sodium channel 1.8  Conformational restriction  Pharmacokinetic  Structure-activity relationship  Analgesic   Structure-activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289, 页码: 15 作者:  Tang, Siyuan;  Hu, Shuyang;  Feng, Lijing;  Kong, Linghui;  Gui, Jiangwen   |  收藏  |  浏览/下载：18/0  |  提交时间：2025/05/27 N-Cyclopropylmethyl-nornepenthones  Structure-activity relationship  MOR antagonist  KOR agonist  Substance use disorder   Development of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289, 页码: 17 作者:  Zhang, Deyan;  Liu, Lu;  Li, Ming;  Hu, Xinyi   |  收藏  |  浏览/下载：17/0  |  提交时间：2025/04/24 RNA modification  N 6-methyladenosine  Demethylase FTO  Structure-activity relationship  Antileukemia   Structure-Based Discovery of a Series of Novel MAT2a Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2025, 页码: 5 作者:  Zhou, Yushan;  Wang, Li;  Ren, Ruyue;  Zhang, Junjie;  Huan, Xiajuan   |  收藏  |  浏览/下载：14/0  |  提交时间：2025/05/27 MAT2a  MTAP  Synthetic lethality  Allosteric inhibitor  Structure-activity relationship   Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：36/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 155, 页码: 15 作者:  Yu, Nai-Rong;  Huang, Suling;  Deng, Zhen-Tao;  Wang, Jiayue   |  收藏  |  浏览/下载：36/0  |  提交时间：2025/04/01 Non-alcoholic steatohepatitis (NASH)  Alisol B  Structural modification  Structure-activity relationship  HFD+CCl4-induced NASH mice model   Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：27/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 277, 页码: 17 作者:  Zhuang, Zhen;  Miao, Yu-Ling;  Song, Shan-Shan;  Leng, Guang-Tong;  Zhang, Xiao-Fei   |  收藏  |  浏览/下载：43/0  |  提交时间：2024/09/26 USP7 inhibitor  Structure-activity relationships  Anti-cancer  pyrrolo[2,3-d]pyrimidin-4-one   Cytotoxic diterpenoids from Croton kongensis inhibiting tumor proliferation and migration 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 152, 页码: 15 作者:  Zhu, Qiong;  Li, Ying;  Wang, Chenglei;  Yu, Jinhai;  Yue, Jianmin   |  收藏  |  浏览/下载：37/0  |  提交时间：2024/10/21 Croton kongensis  ent-Kauranes  Structural elucidation  Structure-activity relationship  Anticancer mechanism