机构

• 上海药物研究所 [57]
• 昆明植物研究所 [29]
• 化学研究所 [9]
• 大连化学物理研究所 [7]
• 过程工程研究所 [5]
• 兰州化学物理研究所 [5]
• 更多

采集方式

• OAI收割 [131]
• iSwitch采集 [3]

内容类型

• 期刊论文 [133]
• 学位论文 [1]

发表日期

• 2024 [3]
• 2023 [5]
• 2022 [12]
• 2021 [10]
• 2020 [7]
• 2019 [7]
• 更多

学科主题

• Chemistry,... [7]
• Chemistry [4]
• Chemistry,... [4]
• Pharmacolo... [4]
• Chemistry,... [3]
• 分析化学与药物化学 [2]
• 更多

筛选

浏览/检索结果: 共134条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 277, 页码: 17 作者:  Zhuang, Zhen;  Miao, Yu-Ling;  Song, Shan-Shan;  Leng, Guang-Tong;  Zhang, Xiao-Fei   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/09/26 USP7 inhibitor  Structure-activity relationships  Anti-cancer  pyrrolo[2,3-d]pyrimidin-4-one   Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H)-one derivatives as potent USP1 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 275, 页码: 18 作者:  Li, Hongrui;  Liu, Ben-Jin;  Xu, Jiahao;  Song, Shan-Shan;  Ba, Ruixian   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/08/22 USP1 inhibitor  Structure -activity relationships  Olaparib-resistant cell   Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107, 页码: 8 作者:  Wei, Yueyue;  Xiong, Yuan;  Liao, Qingyi;  Yang, Ya;  Tian, Tian   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/07/12 8-naphthalimide  Structure -activity relationships (SAR)  Paclitaxel (PTX) resistance  Molecular docking   Structure-based discovery of potent USP28 inhibitors derived from Vismodegib 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15 作者:  Zhou, Di;  Xu, Zhuo;  Huang, Yaodong;  Wang, Hui;  Zhu, Xiaoli   |  收藏  |  浏览/下载：39/0  |  提交时间：2023/10/17 USP28  Structure-based  Vismodegib derivatives  Structure-activity relationships  c-Myc   Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors 期刊论文  OAI收割 CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 卷号: 378, 页码: 11 作者:  Yang, Yun;  Xiong, Yuan;  Zhu, Guanghao;  Sun, Mengru;  Zou, Kun   |  收藏  |  浏览/下载：34/0  |  提交时间：2023/10/17 Human carboxylesterase 2 (hCES2A)  Berberine analogues  Structure -activity relationships (SAR)  Inhibition kinetics  Selectivity   Design, synthesis, and evaluation of pyrido.[3,4-b]pyrazin-2(1H)-one derivatives as potent FLT3 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 79, 页码: 117155 作者:  Sun, Mei;  Wang, Chang;  Wang, Peipei;  Ye, Qingqing;  Zhou, Yubo   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/04/09 FLT3  FLT3-D835Y  Acute myeloid leukemia  Structure -activity relationships   Design, synthesis and biological evaluation of KRASG12C-PROTACs 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14 作者:  Zhang, Xiaoyi;  Zhao, Tong;  Sun, Minghao;  Li, Pei;  Lai, Mengzhen   |  收藏  |  浏览/下载：25/0  |  提交时间：2023/04/10 KRASG12C  PROTAC  Covalent inhibitors  Structure-activity relationships (SARs)  Anticancer   Development of actein derivatives as potent anti-triple negative breast cancer agents 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 89, 页码: 129307 作者:  Zhang,Honglin;  Chen,Yiyan;  Huang,Songwen;  Xiao,Wen-Wen;  Qiu,Ming-Hua   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/07/22 Actein  Modification  Triple negative breast cancer  Structure-activity relationships  Mechanism  GROWTH-INHIBITORY ACTIVITY  BLACK COHOSH  EXTRACTS   Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study 期刊论文  OAI收割 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1411-1425 作者:  Sun, Yin;  Tang, Haotian;  Wang, Xiaoyan;  Feng, Fang;  Fan, Tiantian   |  收藏  |  浏览/下载：49/0  |  提交时间：2022/08/16 TBK1 inhibitors  1H-pyrazolo[3  4-b]pyridine  structure-activity relationships (SARs)  immune response  cancer therapy   Development and structure–activity relationships of tanshinones as selective 11β-hydroxysteroid dehydrogenase 1 inhibitors 期刊论文  OAI收割 Natural Products and Bioprospecting, 2022, 卷号: 12, 期号: 1 作者:  Deng,Xu;  Huang,Su-Ling;  Ren,Jian;  Pan,Zheng-Hong;  Shen,Yu   |  收藏  |  浏览/下载：37/0  |  提交时间：2022/11/11 Metabolic syndrome  Tanshinones  Selective 11β-HSD1 inhibitors  Structure–activity relationships