机构

• 上海药物研究所 [10]
• 过程工程研究所 [2]
• 大连化学物理研究所 [1]
• 上海生物化学与细胞生... [1]
• 长春应用化学研究所 [1]

采集方式

• OAI收割 [15]

内容类型

• 期刊论文 [15]

发表日期

• 2025 [2]
• 2022 [1]
• 2021 [3]
• 2020 [1]
• 2018 [1]
• 2017 [2]
• 更多

学科主题

• Biotechnol... [1]

筛选

浏览/检索结果: 共15条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Characterization of the specific proteins to which HH-A, a drug that alleviates ischemic brain injury, binds in rat plasma 期刊论文  OAI收割 DRUG METABOLISM AND DISPOSITION, 2025, 卷号: 53, 期号: 7, 页码: 15 作者:  Zhao, Jie;  Zheng, Yuandong;  Lei, Peng;  Zhang, Yuying;  Zhang, Pingping   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/08/20 Stroke  Covalent binding  HH-A  Ischemic brain injury  Proteomics   Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：36/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog 期刊论文  OAI收割 CURRENT DRUG METABOLISM, 2022, 卷号: 23, 期号: 11, 页码: 928-939 作者:  Tian, Qianqian;  Jiang, Jinfang;  Yin, Hanwei;  Zhang, Yifan;  Li, Yilin   |  收藏  |  浏览/下载：30/0  |  提交时间：2023/04/10 Butaselen  ebselen  covalent binding  Se-methylation  cytosol  TPMT   Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10 作者:     |  收藏  |  浏览/下载：99/0  |  提交时间：2021/06/11 metabolism  mass balance  distribution  covalent binding  furmonertinib   Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10 作者:  Meng, Jian;  Zhang, Hua;  Bao, Jing-jing;  Chen, Zhen-dong;  Liu, Xiao-yun   |  收藏  |  浏览/下载：80/0  |  提交时间：2021/06/11 metabolism  mass balance  distribution  covalent binding  furmonertinib   p Metabolite Identification in the Preclinical and Clinical Phase of Drug Development 期刊论文  OAI收割 CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 11, 页码: 838-857 作者:     |  收藏  |  浏览/下载：47/0  |  提交时间：2022/06/15 Metabolite identification  drug toxicity  drug exposure  covalent-binding drug  drug safety  natural medicines   Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins 期刊论文  OAI收割 DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 35, 期号: 5, 页码: 456-465 作者:  Liu, Xiaoyun;  Feng, Dan;  Zheng, Mingyue;  Cui, Yongmei;  Zhong, Dafang   |  收藏  |  浏览/下载：58/0  |  提交时间：2020/12/21 Covalent tyrosine kinase inhibitors  Covalent binding  Human serum albumin  Molecular docking  Quantitative calculations  Linear modeling  Species difference   Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity 期刊论文  OAI收割 JOURNAL OF FOOD AND DRUG ANALYSIS, 2018, 卷号: 26, 期号: 3, 页码: 965-972 作者:  Ma, Jiang;  Xia, Qingsu;  Fu, Peter P.;  Lin, Ge   |  收藏  |  浏览/下载：63/0  |  提交时间：2019/01/08 Pyrrolizidine alkaloids  Pyrrole-protein adducts  Covalent binding  Target protein  Mechanism-based biomarker  Clinical diagnosis   Transformation of halobenzoquinones with the presence of amino acids in water: Products, pathways and toxicity 期刊论文  OAI收割 WATER RESEARCH, 2017, 卷号: 122, 页码: 299-307 作者:  Du, Penghui;  Zhao, He;  Cao, Hongbin;  Huang, Ching-Hua;  Liu, Wen   |  收藏  |  浏览/下载：50/0  |  提交时间：2017/11/27 Disinfection Byproducts (Dbps)  Halobenzoquinone (Hbq)  Amino Acids  Nucleophilic Reaction  Covalent Binding  Toxicity   Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action 期刊论文  OAI收割 CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 89, 期号: 5, 页码: 655-662 作者:  Wu, Sijin;  Zhang, Keren;  Qin, Hongqiang;  Niu, Mingshan;  Zhao, Weijie   |  收藏  |  浏览/下载：45/0  |  提交时间：2017/10/29 Caffeic Acid Phenethyl Ester  Covalent Binding  Nuclear Export  Xpo1  Crm1