机构

• 上海药物研究所 [15]
• 合肥物质科学研究院 [10]
• 广州生物医药与健康研... [5]

采集方式

• OAI收割 [30]

内容类型

• 期刊论文 [30]

发表日期

• 2024 [1]
• 2023 [1]
• 2022 [2]
• 2021 [4]
• 2020 [1]
• 2019 [1]
• 更多

学科主题

• Chemistry [2]
• Pharmacolo... [2]

筛选

浏览/检索结果: 共30条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 16 作者:  Sun, Yaoliang;  Chen, Zhiwen;  Liu, Guobin;  Chen, Xiaoai;  Shi, Zihan   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/03/25 Inhibitor  Cancer  Threonine tyrosine kinase (TTK)  Covalent   Covalent Binding Mechanism of Furmonertinib and Osimertinib With Human Serum AlbuminS 期刊论文  OAI收割 DRUG METABOLISM AND DISPOSITION, 2023, 卷号: 51, 期号: 1, 页码: 8-16 作者:  Wu, Yali;  Chen, Lili;  Chen, Jian;  Xue, Hao;  He, Qingfeng   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2022, 页码: 8 作者:  Li, Linjie;  Su, Mingbo;  Lu, Weiwei;  Song, Hongzhi;  Liu, Jiaxiang   |  收藏  |  浏览/下载：20/0  |  提交时间：2022/09/30 DNA encoded library  covalent library  library design  covalent inhibitors   Discovery of Pteridine-7(8H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK) 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 3, 页码: 2694-2709 作者:  Dou, Dou;  Diao, Yanyan;  Sha, Wenjie;  Su, Rongrong;  Tong, Linjiang   |  收藏  |  浏览/下载：24/0  |  提交时间：2022/08/16 Discover Novel Covalent Inhibitors Targeting FLT3 through Hybrid Virtual Screening Strategy 期刊论文  OAI收割 BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2021, 卷号: 44, 期号: 12, 页码: 1872-1877 作者:  Hu, Shengquan;  Liu, Jing;  Chen, Sikang;  Gao, Jian;  Zhou, Yubo   |  收藏  |  浏览/下载：21/0  |  提交时间：2022/06/15 acute myeloid leukemia  FMS-like tyrosine kinase 3  CovDock  hybrid virtual screening  autodock   Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 219, 页码: 12 作者:  Rao, Danni;  Li, Heng;  Ren, Xuelian;  Sun, Yaoliang;  Wen, Cuiyun   |  收藏  |  浏览/下载：26/0  |  提交时间：2021/08/17 Zeta-chain associated protein kinase 70 kDa (ZAP-70)  Covalent inhibitor  T cell  Autoimmune diseases   Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794 作者:  Wu, Xiaowei;  Dai, Mengdi;  Cui, Rongrong;  Wang, Yulan;  Li, Chunpu   |  收藏  |  浏览/下载：35/0  |  提交时间：2021/05/24 Tyrosine kinase  Covalent FGFR inhibitors  Virtual screening  Pyrazolo[3,4-d] pyridazinone  Structure-activity relationships  Antitumor efficacy   p Metabolite Identification in the Preclinical and Clinical Phase of Drug Development 期刊论文  OAI收割 CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 11, 页码: 838-857 作者:  Wu, Yali;  Pan, Lulu;  Chen, Zhendong;  Zheng, Yuandong;  Diao, Xingxing   |  收藏  |  浏览/下载：16/0  |  提交时间：2022/06/15 Metabolite identification  drug toxicity  drug exposure  covalent-binding drug  drug safety  natural medicines   Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins 期刊论文  OAI收割 DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 35, 期号: 5, 页码: 456-465 作者:  Liu, Xiaoyun;  Feng, Dan;  Zheng, Mingyue;  Cui, Yongmei;  Zhong, Dafang   |  收藏  |  浏览/下载：29/0  |  提交时间：2020/12/21 Covalent tyrosine kinase inhibitors  Covalent binding  Human serum albumin  Molecular docking  Quantitative calculations  Linear modeling  Species difference   Design, synthesis and biological study of potent and covalent HER-2 tyrosine kinase inhibitors with low cytotoxicity in vitro 期刊论文  OAI收割 CHEMICAL PAPERS, 2019, 卷号: 73, 期号: 6, 页码: 1333-1345 作者:  Jin, Shuyu;  Sun, Xiuyun;  Liu, Dan;  Xie, Hua;  Rao, Yu   |  收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01 HER-2 inhibitors  4-Anilino-3-cyanoquinoline  Covalent  Anticancer activity