机构

• 上海药物研究所 [19]
• 合肥物质科学研究院 [1]

采集方式

• OAI收割 [20]

内容类型

• 期刊论文 [20]

发表日期

• 2024 [1]
• 2021 [3]
• 2020 [2]
• 2018 [1]
• 2017 [1]
• 2016 [2]
• 更多

学科主题

• Chemistry [1]
• Pharmacolo... [1]

筛选

浏览/检索结果: 共20条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   Analysis and Design of a 100 kA HTS Current Lead for CFETR 期刊论文  OAI收割 IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, 2021, 卷号: 31 作者:  He, Fuchao;  Ding, Kaizhong;  Liu, Chenglian;  Liu, Huajun;  Song, Yuntao   |  收藏  |  浏览/下载：65/0  |  提交时间：2021/11/15 CFETR  current lead  HTS  optimization design  thermodynamic analysis   Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13 作者:  Zhou, Yu;  Li, Xiaoguang;  Chen, Kerong;  Ba, Qian;  Zhang, Xu   |  收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24 Structural optimization  Lead compound  Artemisinin derivatives  Cancer   Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13 作者:     |  收藏  |  浏览/下载：31/0  |  提交时间：2021/06/11 Structural optimization  Lead compound  Artemisinin derivatives  Cancer   先导化合物结构优化策略七肽类分子结构修饰与改造 期刊论文  OAI收割 药学学报, 2020, 卷号: 55, 期号: 3, 页码: 427 作者:  彭晶晶;  王江;  戴文豪;  谢雄;  柳红   |  收藏  |  浏览/下载：55/0  |  提交时间：2020/07/01 peptide  structure optimization  drug design  lead compound  多肽  结构改造  药物设计  先导化合物   Bioactivity Prediction Based on Matched Molecular Pair and Matched Molecular Series Methods 期刊论文  OAI收割 CURRENT PHARMACEUTICAL DESIGN, 2020, 卷号: 26, 期号: 33, 页码: 4195-4205 作者:     |  收藏  |  浏览/下载：31/0  |  提交时间：2020/12/21 Matched molecular pair  matched molecular series  bioactivity prediction  SAR transfer  application domain  lead optimization   Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2018, 卷号: 38, 期号: 3, 页码: 914-950 作者:  Zheng, Mingyue;  Zhao, Jihui;  Cui, Chen;  Fu, Zunyun;  Li, Xutong   |  收藏  |  浏览/下载：56/0  |  提交时间：2019/01/08 ADMET  chemical biology  drug design  in silico  lead optimization  molecular dynamics  polypharmacology  virtual screening   Optimization and Synthesis of Pyridazinone Derivatives as Novel Inhibitors of Hepatitis B Virus by Inducing Genome-free Capsid Formation 期刊论文  OAI收割 ACS INFECTIOUS DISEASES, 2017, 卷号: 3, 期号: 3, 页码: 199-205 作者:  Lu, Dong;  Liu, Feifei;  Xing, Weiqiang;  Tong, Xiankun;  Wang, Lang   |  收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 pyridazinone  HBV DNA-free capsids  drug-like optimization  SAR study  lead candidate   Application of Sulfonyl in Drug Design 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 卷号: 36, 期号: 3, 页码: 490-501 作者:  Zhao Fei;  Wang Jiang;  Ding Xiao;  Shu Shuangjie;  Liu Hong   |  收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 sulfonyl  drug design  lead optimization   Lead compound optimization strategy (5) - reducing the hERG cardiac toxicity in drug development 期刊论文  OAI收割 Acta Pharmaceutica Sinica, 2016, 卷号: 51, 期号: 10, 页码: 1530-1539 作者:  Zhou Shengbin;  Wang Jiang;  Liu Hong   |  收藏  |  浏览/下载：54/0  |  提交时间：2019/01/08 hERG  lead compound optimization  lipophilicity  basicity  conformation restriction  cardiac toxicity