中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [15]
大连化学物理研究所 [4]
化学研究所 [2]
采集方式
OAI收割 [21]
内容类型
期刊论文 [21]
发表日期
2024 [2]
2023 [2]
2022 [2]
2021 [1]
2020 [3]
2019 [2]
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Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 16
作者:
Cheng, Chen
;
Ren, Chao
;
Li, Mu-zi
;
Liu, Yi-hui
;
Yao, Ren-qi
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/02/27
Traditional Chinese medicine
XueBiJing
sepsis
mortality
pharmacokinetic compatibility
polypharmacology
A proteomic landscape of pharmacologic perturbations for functional relevance
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2024, 卷号: 14, 期号: 1, 页码: 128-139
作者:
Liu, Zhiwei
;
Jiang, Shangwen
;
Hao, Bingbing
;
Xie, Shuyu
;
Liu, Yingluo
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/04/09
Proteomics
Drug
Perturbation
Drug target
Drug combination
Recognition of methamphetamine and other amines by trace amine receptor TAAR1
期刊论文
OAI收割
NATURE, 2023, 卷号: 624, 期号: 7992, 页码: 663-+
作者:
Liu, Heng
;
Zheng, You
;
Wang, Yue
;
Wang, Yumeng
;
He, Xinheng
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/25
Structural genomics of the human dopamine receptor system
期刊论文
OAI收割
CELL RESEARCH, 2023, 页码: 13
作者:
Xu, Peiyu
;
Huang, Sijie
;
Krumm, Brian E.
;
Zhuang, Youwen
;
Mao, Chunyou
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/17
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
Darbalaei, Sanaz
;
Chang, Ru-lue
;
Zhou, Qing-tong
;
Chen, Yan
;
Dai, An-tao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/09/30
glucagon-like peptide-1 receptor
glucagon receptor
dual and triple agonist
cAMP
pERK1/2
unimolecular polypharmacology
Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy br
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 6, 页码: 4818-4831
作者:
Wu, Shanchao
;
Huang, Yahui
;
Wang, Ting
;
Li, Keliang
;
Lu, Junjie
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/08/16
Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge
期刊论文
OAI收割
PLOS COMPUTATIONAL BIOLOGY, 2021, 卷号: 17, 期号: 9, 页码: 19
作者:
Xiong, Zhaoping
;
Jeon, Minji
;
Allaway, Robert J.
;
Kang, Jaewoo
;
Park, Donghyeon
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/11/04
Automated design and optimization of multitarget schizophrenia drug candidates by deep learning
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 204, 页码: 16
作者:
Tan, Xiaoqin
;
Jiang, Xiangrui
;
He, Yang
;
Zhong, Feisheng
;
Li, Xutong
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/12/21
Schizophrenia
Multitarget antipsychotic drugs
Recurrent neural network
Multitask deep neural network
Automated drug design
Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737
作者:
Li, Xutong
;
Li, Zhaojun
;
Wu, Xiaolong
;
Xiong, Zhaoping
;
Yang, Tianbiao
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/12/21
Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737
作者:
Li, Xutong
;
Li, Zhaojun
;
Wu, Xiaolong
;
Xiong, Zhaoping
;
Yang, Tianbiao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/12/21