机构

• 化学研究所 [5]
• 上海药物研究所 [5]
• 生态环境研究中心 [2]
• 长春应用化学研究所 [2]
• 南海海洋研究所 [1]
• 烟台海岸带研究所 [1]
• 更多

采集方式

• OAI收割 [16]

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浏览/检索结果: 共16条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Organobromine compounds in aquatic environments: Embryotoxicity linked to lipophilicity and molecular structure 期刊论文  OAI收割 JOURNAL OF HAZARDOUS MATERIALS, 2025, 卷号: 489, 页码: 14 作者:  Hou, Zhihao;  Shi, Zhenzhen;  Lu, Zhen;  Wang, Derui;  Yan, Zhi   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/05/09 Bromophenols  Acute toxicity  Lipophilicity  Retinol metabolism  Myocardial contraction   Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into 8-position to the carboxylic acid 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115267 作者:  Chen, Cheng;  Guo, Shi-Meng;  Sun, Yuanjun;  Li, He;  Hu, Nan   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/03/27 GPR40  Glucose-stimulated insulin secretion  Type 2 diabetes mellitus  Lipophilicity  Liver safety  Three-in-one pharmacophore  2-(phenylsulfinyl)acetic acid   Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity 期刊论文  OAI收割 ANTIOXIDANTS, 2021, 卷号: 10, 期号: 5, 页码: - 作者:  Shao, Bo;  Mao, Li;  Tang, Miao;  Yan, Zhu-Ying;  Shao, Jie   |  收藏  |  浏览/下载：15/0  |  提交时间：2021/12/22 caffeic acid phenethyl ester  iron  DNA damage  hydroxyl radical  redox-inactive iron complex  lipophilicity   Simultaneous determination of the lipophilicity and dissociation constants of dialkyl phosphinic acids by negligible depletion hollow fiber membrane-protected liquid-phase microextraction 期刊论文  OAI收割 JOURNAL OF CHROMATOGRAPHY A, 2017, 卷号: 1507, 期号: 0, 页码: 11-17 作者:  Shi, Fengqiong;  Liu, Jingfu   |  收藏  |  浏览/下载：20/0  |  提交时间：2018/07/26 Dialkyl Phosphinic Acids (Dpas)  Lipophilicity (Log d)  Dissociation Constant (Pk(a))  Hollow Fiber  Uplc-ms/ms   Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects 期刊论文  OAI收割 CURRENT MEDICINAL CHEMISTRY, 2017, 卷号: 24, 期号: 35, 页码: 3921-3937 作者:  Cao, Hua;  Wang, Kai;  Ye, Yang-Liang;  Shen, Jian-Hua   |  收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08 Intestine targeted drugs  design strategies  lipophilicity  aqueous solubility  molecular weight  soft drugs  prodrugs  efflux transporters   Design, synthesis and cytotoxic activities of novel 2,5-diketopiperazine derivatives 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 121, 页码: 500-509 作者:  Liao, Sheng-Rong;  Qin, Xiao-Chu;  Wang, Zhen;  Li, Ding;  Xu, Liang 收藏  |  浏览/下载：24/0  |  提交时间：2016/12/22 2,5-Diketopiperazine derivatives  Long alkyl chain  Cytotoxic activity  Apoptosis  Lipophilicity   Lead compound optimization strategy (5) - reducing the hERG cardiac toxicity in drug development 期刊论文  OAI收割 Acta Pharmaceutica Sinica, 2016, 卷号: 51, 期号: 10, 页码: 1530-1539 作者:  Zhou Shengbin;  Wang Jiang;  Liu Hong   |  收藏  |  浏览/下载：56/0  |  提交时间：2019/01/08 hERG  lead compound optimization  lipophilicity  basicity  conformation restriction  cardiac toxicity   Application of phosphates and phosphonates prodrugs in drug research and development 期刊论文  OAI收割 Acta Pharmaceutica Sinica, 2013, 卷号: 48, 期号: 5, 页码: 621-634 作者:  Ji Xun;  Wang Jiang;  Zhang Lei;  Zhao Linxiang;  Jiang Hualiang   |  收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 prodrugs of phosphates and phosphonates  bioavailability  lipophilicity  solubility  stability  HepDirect prodrug   Lead compound optimization strategy (1)changing metabolic pathways and optimizing metabolism stability 期刊论文  OAI收割 Acta Pharmaceutica Sinica, 2013, 卷号: 48, 期号: 10, 页码: 1521-1531 作者:  Wang Jiang;  Liu Hong   |  收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 metabolism stability  lead compound  block metabolic site  lipophilicity  half life   Improvement in the assessment of direct and facilitated ion transfers by electrochemically induced redox transformations of common molecular probes 期刊论文  OAI收割 physical chemistry chemical physics, 2012, 卷号: 14, 期号: 10, 页码: 3659-3668 Zhou M; Gan SY; Zhong LJ; Dong XD; Ulstrup J; Han DX; Niu L 收藏  |  浏览/下载：29/0  |  提交时间：2013/08/29 ALKALI-METAL CATIONS  WATER/1  LIQUID INTERFACE  2-DICHLOROETHANE INTERFACE  PARTITION DIAGRAMS  3-PHASE ELECTRODE  GIBBS ENERGIES  WATER  VOLTAMMETRY  MEMBRANE  LIPOPHILICITY