中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [27]
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上海生物化学与细胞生... [6]
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期刊论文 [71]
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Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16
作者:
Zeng, Gongruixue
;
Xu, Gaoya
;
Gao, Lixin
;
Zheng, Xiaoli
;
Chi, Xinglong
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
Proteasome inhibitors
Macrocycle
Stability
Anti-cancer activities
Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 145, 页码: 17
作者:
Yu, Qian
;
Wang, Zheng
;
Tu, Yutong
;
Cao, Yu
;
Zhu, Huajian
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/05/07
20S proteasome
Proteasome activation
IDPs
Undruggable
Protein homeostasis
Proteasome inhibitors reduce CD73 expression partly
via
decreasing p-ERK in NSCLC cells
期刊论文
OAI收割
LIFE SCIENCES, 2023, 卷号: 332, 页码: 10
作者:
Su, Ai-Ling
;
Tian, Chang-Qing
;
Ou, Ying-Jie
;
Bao, Xu-Bin
;
Huan, Xia-Juan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/12/08
CD73
Proteasome inhibitors
ERK
NSCLC
Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 138, 页码: 22
作者:
Wang, Hanlin
;
Wu, Zhaoxiao
;
Cao, Yu
;
Gao, Lixin
;
Shao, Jiaan
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/10/17
Metabolic stability
Four-membered heterocycles
Proteasome inhibitors
Multiple myeloma
Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1088
作者:
Yan,Ying
;
Zhou,Qi
;
Ran,Xiaoqian
;
Lu,Qingyun
;
Zhang,Cuishan
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/05/09
euphjatrophane
Euphorbia peplus
jatrophane diterpenoid
autophagy
Tau pathology
UBIQUITIN-PROTEASOME SYSTEM
MULTIDRUG-RESISTANCE
BIOLOGICAL-ACTIVITY
ALZHEIMERS-DISEASE
MODULATORS
CELLS
Global ubiquitinome analysis reveals the role of E3 ubiquitin ligase FaBRIZ in strawberry fruit ripening
期刊论文
OAI收割
JOURNAL OF EXPERIMENTAL BOTANY, 2023, 卷号: 74, 期号: 1, 页码: 214-232
作者:
Wang, Yuying
;
Kong, Lingxi
;
Wang, Weihao
;
Qin, Guozheng
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/07
Fruit ripening
protein post-translational modification
strawberry
ubiquitination
ubiquitinome
ubiquitin-proteasome system (UPS)
Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy
期刊论文
OAI收割
ORGANIC & BIOMOLECULAR CHEMISTRY, 2023, 卷号: 21, 期号: 3, 页码: 514-519
作者:
Yan,Ying
;
Ran,Xiaoqian
;
Wang,Dan
;
Zhang,Xiong
;
Peng,Mingyou
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/07/25
UBIQUITIN-PROTEASOME SYSTEM
ALZHEIMERS-DISEASE
CONSTITUENTS
LIMONOIDS
TFEB
NEURODEGENERATION
The contribution of proteasomal impairment to autophagy activation by C9orf72 poly-GA aggregates
期刊论文
OAI收割
CELLULAR AND MOLECULAR LIFE SCIENCES, 2022, 卷号: 79, 期号: 9
作者:
Pu, Mei
;
Tai, Yusi
;
Yuan, Luyang
;
Zhang, Yu
;
Guo, Huijie
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/10/09
ALS
C9orf72
Poly-GA
Proteasome
Autophagy
The contribution of proteasomal impairment to autophagy activation by C9orf72 poly-GA aggregates
期刊论文
OAI收割
CELLULAR AND MOLECULAR LIFE SCIENCES, 2022, 卷号: 79, 期号: 9, 页码: 23
作者:
Pu, Mei
;
Tai, Yusi
;
Yuan, Luyang
;
Zhang, Yu
;
Guo, Huijie
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/09/30
ALS
C9orf72
Poly-GA
Proteasome
Autophagy
Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 18
作者:
Cao, Yu
;
Tu, Yutong
;
Fu, Liping
;
Yu, Qian
;
Gao, Lixin
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/06/15
Metabolism
Design
Proteasome inhibitors
Non-covalent
Multiple myeloma