中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
长春应用化学研究所 [12]
上海药物研究所 [10]
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期刊论文 [50]
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2023 [1]
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Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L
期刊论文
OAI收割
CANCERS, 2023, 卷号: 15, 期号: 21, 页码: 28
作者:
Li, Xin
;
Wu, Xiaowei
;
Nie, Shenyou
;
Zhao, Jidong
;
Yao, Yuan
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/12/19
MLL-rearranged leukemia
super elongation complexes
small-molecule inhibitor
protein-protein interaction
cancer therapeutics
Label-Free Detection and Translocation Dynamics Study of Single-Molecule Herceptin Using Solid-State Nanopores
期刊论文
OAI收割
ADVANCED MATERIALS TECHNOLOGIES, 2022
作者:
Hu, Rui
;
Lu, Wenlong
;
Wei, Guanghao
;
Nan, Hexin
;
Li, Juan
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/12/23
solid-state nanopore
single-molecule detection
protein dynamics
monoclonal antibody
protein unfolding
Single-Molecule Identification of the Conformations of Human C-Reactive Protein and Its Aptamer Complex with Solid-State Nanopores
期刊论文
OAI收割
ACS APPLIED MATERIALS & INTERFACES, 2022, 卷号: 14, 期号: 10, 页码: 12077-12088
作者:
Wu, Ji
;
Liang, Liyuan
;
Zhang, Mingkun
;
Zhu, Rui
;
Wang, Zhong
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2022/08/22
solid-state nanopore
C-reactive protein
aptamer
single-molecule
conformation
Nanopore Technology for the Application of Protein Detection
期刊论文
OAI收割
NANOMATERIALS, 2021, 卷号: 11, 期号: 8, 页码: 16
作者:
Zeng, Xiaoqing
;
Xiang, Yang
;
Liu, Qianshan
;
Wang, Liang
;
Ma, Qianyun
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/11/26
nanopore
single-molecule detection
protein detection
solid-state nanopore
Mechanochemical Activation of Class-B G-Protein-Coupled Receptor upon Peptide-Ligand Binding
期刊论文
OAI收割
NANO LETTERS, 2020, 卷号: 20, 期号: 7, 页码: 5575-5582
作者:
Lo Giudice, Cristina
;
Zhang, Haonan
;
Wu, Beili
;
Alsteens, David
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/12/24
Atomic force microscopy
single-molecule force spectroscopy
human glucagon receptor
G-protein-coupled receptors
mechanotransduction
A patent review of BRD4 inhibitors (2013-2019)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2020, 卷号: 30, 期号: 1, 页码: 57-81
作者:
Lu, Tian
;
Lu, Wenchao
;
Luo, Cheng
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
Bromodomain-containing protein 4 (BRD4)
bromodomain and extra-terminal (BET) family
small molecule inhibitors
cancer
patent
therapeutic potential
Atomic Force Microscopy as a Powerful Multifunctional Tool for Probing the Behaviors of Single Proteins
期刊论文
OAI收割
IEEE TRANSACTIONS ON NANOBIOSCIENCE, 2020, 卷号: 19, 期号: 1, 页码: 78-99
作者:
Li M(李密)
;
Wang YC(王越超)
;
Liu LQ(刘连庆)
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/02/17
Atomic force microscopy (AFM)
single-protein analysis
morphological imaging
single-molecule force recognition
mechanical unfolding
high-speed AFM
A patent review of arginine methyltransferase inhibitors (2010-2018)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2019, 卷号: 29, 期号: 2, 页码: 97-114
作者:
Li, Xiao
;
Wang, Chen
;
Jiang, Hao
;
Luo, Cheng
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
Arginine methylation
Protein arginine methyltransferases (PRMTs)
small molecule inhibitors
drug research and development
The plant sesquiterpene lactone parthenolide inhibits Wnt/-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 14, 页码: 5335-5344
作者:
Zhu, Xiaoliang
;
Yuan, Chunmao
;
Tian, Chenyang
;
Li, Chen
;
Nie, Fen
  |  
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2018/05/08
Inhibitor
Protein Synthesis
Small Molecule
T-cell Factor (Tcf)
Wnt Signaling
Exploring the Spatiotemporal Organization of Membrane Proteins in Living Plant Cells
期刊论文
OAI收割
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 69, 2018, 卷号: 69, 页码: 525-551
作者:
Wang, Li
;
Xue, Yiqun
;
Xing, Jingjing
;
Song, Kai
;
Lin, Jinxing
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/02/25
membrane proteins
single-molecule techniques
assembly stoichiometry
protein interaction
membrane microdomain
cytoskeleton