中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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化学研究所 [46]
大连化学物理研究所 [26]
长春应用化学研究所 [26]
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期刊论文 [210]
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Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 7, 页码: 3286-3290
作者:
Zheng, Miao
;
Feng, Bo
;
Zhang, Yumin
;
Liu, Xin
;
Zhao, Na
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/08/22
Non-covalent PLpro inhibitors
Antiviral activity
Structural-based drug design
Imidazo[4,5-b]pyridine scaffold
Macrolide sesquiterpene pyridine alkaloids from Celastrus monospermus and evaluation of their immunosuppressive and anti-osteoclastogenesis activities
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 145, 页码: 14
作者:
Ning, Ruonan
;
Zhao, Jie
;
Chen, Li
;
Mu, Hongyan
;
Chen, Zhongxian
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/05/31
Macrolide sesquiterpene pyridine alkaloid
Celastrus monospermus Roxb
Immunosuppressive
Anti-osteoclastogenesis
Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1411-1425
作者:
Sun, Yin
;
Tang, Haotian
;
Wang, Xiaoyan
;
Feng, Fang
;
Fan, Tiantian
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2022/08/16
TBK1 inhibitors
1H-pyrazolo[3
4-b]pyridine
structure-activity relationships (SARs)
immune response
cancer therapy
Effects of pyridine-like and pyrrolic-like nitrogen on the photoluminescence blue-shift of nitrogen-doped graphene oxide quantum dots
期刊论文
OAI收割
JOURNAL OF LUMINESCENCE, 2021, 卷号: 235
作者:
Chen, Junxin
;
Xu, Xiaofen
;
Ma, Yuqiu
;
Qin, Haijun
;
Liu, Jun
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/05/31
Photoluminescence
Blue-shift
Pyridine-like nitrogen
Pyrrolic-like nitrogen
Graphene oxide quantum dots
Evaluating the effect of fenton pretreated pyridine wastewater under different biological conditions: Microbial diversity and biotransformation pathways
期刊论文
OAI收割
JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2021, 卷号: 287, 页码: -
作者:
Guadie, Awoke
;
Han, Jing-Long
;
Liu, Wenzong
;
Ding, Yang-Cheng
;
Minale, Mengist
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/12/23
Pyridine
Microbial community
Fenton pretreatment
Mineralization
Biodegradation
Live cell mitochondrial 3-dimensional dynamic ultrastructures under oxidative phosphorylation revealed by a Pyridine-BODIPY probe
期刊论文
OAI收割
BIOSENSORS & BIOELECTRONICS, 2021, 卷号: 178
作者:
Zhu, Tong
;
Yang, Guanqing
;
Liu, Xiaolu
;
Xiang, Pan
;
Yang, Zhenghui
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/04/26
Mitochondrial ultrastructure
3-Dimensional dynamic
Oxidative phosphorylation
BODIPY-Pyridine derivative
STED nanoscopy
Insight into the Mechanism of Glycerol Dehydration and Subsequent Pyridine Synthesis
期刊论文
OAI收割
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, 卷号: 9, 期号: 8, 页码: 3095-3103
作者:
Jiang, Ding
;
Wang, Shuang
;
Li, Hongping
;
Xu, Lujiang
;
Hu, Xun
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/10/27
thermal decomposition
glycerol
pyrolysis
pyridine
pyridine synthesis
Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 33, 页码: 127749
作者:
Yang, Bowen
;
Wu, Qian
;
Huan, Xiajuan
;
Wang, Yingqing
;
Sun, Yin
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/03/21
TNIK inhibitor
1H-pyrrolo[2,3-b]pyridine
IL-2 secretion inhibitory
Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)
期刊论文
OAI收割
MOLECULES, 2021, 卷号: 26, 期号: 16, 页码: 4934
作者:
Zhang,Ranran
;
Liu,Junhong
;
Yan,Hui
;
Peng,Xingrong
;
Zhang,Ling
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/04/02
Lepidium meyenii
thiohydantoins
thioxohexahydroimidazo [1
5-a] pyridine
neuroprotective activities
IMIDAZOLE ALKALOIDS
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