中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [30]
采集方式
OAI收割 [30]
内容类型
期刊论文 [30]
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2023 [4]
2022 [2]
2021 [1]
2020 [1]
2018 [3]
2017 [1]
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Biochemist... [2]
Life Scien... [1]
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专题:上海药物研究所
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Physiological and Pathological Functions of TRPM7 Channel and Its Small-molecule Modulators
期刊论文
OAI收割
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2023, 卷号: 50, 期号: 12, 页码: 2856-2868
作者:
Wang, Yun-Qi
;
Guan, Zi-Yue
;
Gao, Zhao-Bing
;
Zheng, Yue-Ming
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/04/09
TRPM7
ion channel
physiological function
disease
small molecule modulators
TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 卷号: 8, 期号: 1, 页码: 38
作者:
Zhang, Miao
;
Ma, Yueming
;
Ye, Xianglu
;
Zhang, Ning
;
Pan, Lei
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4-difluor- oazepan-1-yl)-6-methyl nicotinamide scaffold for the treatment of pain
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 12
作者:
Qin, Hui
;
Wei, Aihuan
;
Wang, Yunqi
;
Wang, Linlin
;
Xu, Haiyan
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/17
Pain
Non-addictive analgesics
Na V 1
8-selective inhibitors
Bicyclic aromatic groups
Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 9
作者:
Wang, Qiao-qiao
;
Wang, Long
;
Zhang, Wen-bo
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/10/17
Nav1.7 channel
naphthylisoquinolines
Ancistrocladus tectorius
dorsal root ganglion neurons
formalin-induced mouse inflammatory pain model
analgesics
Molecular Determinants for the High-Affinity Blockade of Human Ether-a-go-go-Related Gene K+ Channel by Tolterodine
期刊论文
OAI收割
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2022, 卷号: 80, 期号: 5, 页码: 679-689
作者:
Wang, Na
;
Yang, Yang
;
Wen, Jing
;
Fan, Xin-Rong
;
Li, Jian
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/12/13
tolterodine
hERG channel
molecular docking
muscarinic acetylcholine receptor
tachycardia
overactive bladder
SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 10
作者:
Guo, Qian-bei
;
Zhan, Li
;
Xu, Hai-yan
;
Gao, Zhao-bing
;
Zheng, Yue-ming
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/08/30
early infantile epileptic encephalopathy type 13
SCN8A
gain-of-function mutation
antiepileptic drugs
phenytoin
carbamazepine
Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5 '-triphosphate in Cellular Applications
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 页码: 10
作者:
Wu, Luling
;
Liu, Jihong
;
Tian, Xue
;
Groleau, Robin R.
;
Feng, Beidou
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/06/15
Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 293-302
作者:
Wang, Jin-tao
;
Zheng, Yue-ming
;
Chen, Yue-ting
;
Gu, Min
;
Gao, Zhao-bing
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Nav1
7 sodium channel
aryl sulfonamide
maprotiline
compound 10o
electrophysiology
acetic acid-induced visceral pain
analgesic activity
A binding-block ion selective mechanism revealed by a Na/K selective channel
期刊论文
OAI收割
PROTEIN & CELL, 2018, 卷号: 9, 期号: 7, 页码: 629-639
作者:
Yu, Jie
;
Zhang, Bing
;
Zhang, Yixiao
;
Xu, Cong-qiao
;
Zhuo, Wei
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
cryo-EM
MscS
Na+/K+ selective channel
Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 4, 页码: 587-596
作者:
Zheng, Yue-ming
;
Wang, Wan-fu
;
Li, Yan-fen
;
Yu, Yong
;
Gao, Zhao-bing
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
Nav1.7 channels
analgesics
CNV1014802
inactivated state
paroxysmal extreme pain disorder