中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [29]
采集方式
OAI收割 [29]
内容类型
期刊论文 [29]
发表日期
2023 [3]
2022 [5]
2021 [5]
2020 [3]
2019 [1]
2018 [3]
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内容类型:期刊论文
专题:上海药物研究所
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Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3K alpha inhibitors via virtual screening and docking-based structure optimization
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 86, 页码: 15
作者:
Gu, Dongyan
;
Zhang, Mengmeng
;
Cai, Lvtao
;
Wang, Chang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/10/17
PI3K alpha inhibitors
Virtual screening
Structure optimization
Discovery of Highly Potent and Selective Thyroid Hormone Receptor βAgonists for the Treatment of Nonalcoholic Steatohepatitis
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3284-3300
作者:
Hu, Liuyu
;
Gu, Yipei
;
Liang, Ju
;
Ning, Mengmeng
;
Yang, Junli
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/27
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors
期刊论文
OAI收割
PROTEIN & CELL, 2023, 卷号: 14, 期号: 1, 页码: 17-27
作者:
Zang, Yi
;
Su, Mingbo
;
Wang, Qingxing
;
Cheng, Xi
;
Zhang, Wenru
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/27
high-throughput screening
SARS
CoV-2
main
papain-like
proteases
Discovery of a Potent and Selective Degrader for USP7
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 卷号: 61, 期号: 33, 页码: e202204395
作者:
Pei, Yuan
;
Fu, Jingfeng
;
Shi, Yunkai
;
Zhang, Mengmeng
;
Luo, Guanghao
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/21
Apoptotic Pathway
Mutant p53
p53 Mutant Cancer Cells
PROTAC
USP7 Degrader
Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 18
作者:
Cao, Yu
;
Tu, Yutong
;
Fu, Liping
;
Yu, Qian
;
Gao, Lixin
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/06/15
Metabolism
Design
Proteasome inhibitors
Non-covalent
Multiple myeloma
Construction of Aza-spiro[4,5]indole Scaffolds via Rhodium-Catalyzed Regioselective C(4)-H Activation of Indole
期刊论文
OAI收割
ACTA CHIMICA SINICA, 2022, 卷号: 80, 期号: 3, 页码: 277-281
作者:
Wang Mengmeng
;
Zhang Jun
;
Wang Huiying
;
Ma Biao
;
Dai Hui-Xiong
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/06/15
indole spirocycle
C-H activation
Rh-catalyst
Chemical Constituents of Sinularia nanolobata from the South China Sea
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 卷号: 42, 期号: 3, 页码: 891-895
作者:
Zeng Zirong
;
Zhang Mengmeng
;
Wang Hong
;
Li Jia
;
Guo Yuewei
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/08/16
south china sea: Sinularia nanolobata
prenylelemane-type diterpene
protein tyrosine phosphatase-1B (PTPIB) inhibitory activity
Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation
期刊论文
OAI收割
THERANOSTICS, 2022, 卷号: 12, 期号: 11, 页码: 5220-5236
作者:
Guo, Ren
;
Jia, Xiaohui
;
Ding, Zhenbin
;
Wang, Gang
;
Jiang, Mengmeng
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/08/30
Mixed lineage kinase domain-like protein
MLKL
liver fibrosis
liver parenchymal cells
hepatocyte
hepatic stellate cells
necroptosis
Development of peptide epoxyketones as selective immunoproteasome inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 221, 页码: 113556
作者:
Li, Xuemei
;
Hong, Duidui
;
Zhang, Mengmeng
;
Xu, Lei
;
Zhou, Yubo
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/21
Epoxyketones
Immunoproteasome inhibitor
Selectivity
Multiple myeloma
Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C-H activations for modular click chemistry libraries
期刊论文
OAI收割
CHEMICAL COMMUNICATIONS, 2021, 页码: 4
作者:
Zhang, Jun
;
Wang, Mengmeng
;
Wang, Huiying
;
Xu, Hui
;
Chen, Junjie
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/04