中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [39]
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上海生物化学与细胞生... [9]
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期刊论文 [125]
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Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-
d
]pyrimidin-7(6
H
)-one" Scaffold for the Treatment of B Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2884-2906
作者:
Liang, Xuewu
;
Yu, Haolan
;
Liang, Renwen
;
Feng, Zhuanghui
;
Saidahmatov, Abdusaid
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/04/09
Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non-Small Cell Lung Cancer Cells
期刊论文
OAI收割
MOLECULAR CANCER RESEARCH, 2022, 卷号: 20, 期号: 12, 页码: 1785-1798
作者:
Sun, Lin
;
Wu, Qian
;
Huan, Xia-Juan
;
Tian, Chang-Qing
;
Wang, Ying-Qing
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/21
Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 236, 页码: 114327
作者:
Feng, Xuexin
;
Yan, Ziqin
;
Zhou, Feilong
;
Lou, Jianfeng
;
Lyu, Xilin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/21
BFL-1
Apoptosis
Covalent inhibitor
Cytochrome c
BCL-2
Protein-Protein interaction
Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma
期刊论文
OAI收割
CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218
作者:
Chen, Zi-qi
;
Cao, Zhe-rui
;
Wang, Yi
;
Zhang, Xi
;
Xu, Lan
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2021/12/16
CYH33
MYC
P300
BET
B cell lymphoma
PI3K
Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 期号: 5, 页码: 1-15
作者:
Liu, XY (Liu, Xiao Yan) [1] , [2] , [3]
;
Peng, J (Peng, Jun) [1] , [2]
;
He, F (He, Fei) [1]
;
Tursun, X (Tursun, Xirali) [4]
;
Li, SP (Li, Shu Ping) [1]
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/06/06
shabyar
retinal pigment epithelium
autophagy
aldose reductase
traditional medicine formula
BCL-2 inhibitor synergizes with PI3K delta inhibitor and overcomes FLT3 inhibitor resistance in acute myeloid leukaemia
期刊论文
OAI收割
AMERICAN JOURNAL OF CANCER RESEARCH, 2022, 卷号: 12, 期号: 8, 页码: 3829-3842
作者:
Yao, Ming-Yue
;
Wang, Ya-Fang
;
Zhao, Yu
;
Ling, Li-Jun
;
He, Ye
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/13
Acute myeloid leukaemia
BCL-2
PI3K delta
FLT3
synergistic lethality
The PROTAC selectively degrading Bcl-x(L) represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while bone
期刊论文
OAI收割
THERANOSTICS, 2022, 卷号: 12, 期号: 17, 页码: 7476-7490
作者:
Zhang, Shaoqing
;
Chen, Yue
;
Xu, Zhongli
;
Yang, Jun
;
Sun, Renhong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/04/10
Hedgehog
Bcl-xL
PROTAC
drug resistance
bone growth
Preclinical characterization of LOXO-338, a novel, oral and selective BCL2 inhibitor.
期刊论文
OAI收割
CANCER RESEARCH, 2021, 卷号: 81, 期号: 13, 页码: 1
作者:
Brandhuber, Barbara
;
Ku, Karin
;
Lallena, Maria J.
;
Baquero, Carmen
;
Choy, Regina
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/11/04
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15
作者:
Yu, Qing
;
Sun, Yi
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/03/15
anti-cancer drug
cullin-RING E3 ligases
natural product
high-throughput screen
neddylation
small-molecule inhibitors
Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer
期刊论文
OAI收割
CANCER LETTERS, 2021, 卷号: 500
作者:
Zhang, Tao
;
Wu, Bihan
;
Akakuru, Ozioma Udochukwu
;
Yao, Chenyang
;
Sun, Shan
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/12/01
IR-780 DYE
BIIB021
NANOPARTICLES
METABOLISM
DELIVERY
CELLS