中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [36]
昆明植物研究所 [4]
武汉物理与数学研究所 [3]
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期刊论文 [53]
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Obesity induced disruption on diurnal rhythm of insulin sensitivity via gut microbiome-bile acid metabolism
期刊论文
OAI收割
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2024, 卷号: 1869, 期号: 1, 页码: 13
作者:
Guo, Xiaozhen
;
Wang, Jiawen
;
Xu, Hualing
;
Wang, Yangyang
;
Cao, Yutang
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2024/01/16
Diurnal rhythm
Insulin sensitivity
Obesity
Gut microbiota
Ursodeoxycholic acid
Effects of glyphosate exposure on gut-liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus)
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 902, 页码: 12
作者:
Yan, Biao
;
Sun, Yumiao
;
Fu, Kaiyu
;
Zhang, Yindan
;
Lei, Lei
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/01/26
Glyphosate
Metabolomics
Grass carp
Gut-Liver axis
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARa nucleus-cytoplasm shuttling
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 18
作者:
Zhong, Jing
;
He, Xiaofang
;
Gao, Xinxin
;
Liu, Qiaohong
;
Zhao, Yu
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/12/08
Saikosaponins regulate bile acid excretion in mice liver and ileum by activating farnesoid X receptor and bile acid transporter
期刊论文
OAI收割
PHYTOTHERAPY RESEARCH, 2023, 页码: 15
作者:
Wang, YuKun
;
Li, Jing
;
Wu, Li
;
Qin, XueMei
;
Xie, Cen
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/10/17
bile acids
enterohepatic circulation
FXR-related genes
saikosaponins
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 16
作者:
Yan, Ying
;
Niu, Zhoumin
;
Sun, Chao
;
Li, Peng
;
Shen, Siyi
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/12/13
Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 21
作者:
Zhang, Chenlu
;
Liu, Yameng
;
Wang, Ying
;
Ge, Xie
;
Jiao, Tingying
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/11/11
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
期刊论文
OAI收割
CELL STEM CELL, 2022, 卷号: 29, 期号: 9, 页码: 1366-+
作者:
Chen, Li
;
Jiao, Tingying
;
Liu, Weiwei
;
Luo, Yuhong
;
Wang, Jue
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/04/10
Discovery of 9,11-Seco-Cholesterol Derivatives as Novel FXR Antagonists
期刊论文
OAI收割
ACS OMEGA, 2022, 卷号: 7, 期号: 20, 页码: 17401-17405
作者:
Zhou, Jia-Xu
;
Li, Cui-Na
;
Liu, Ya-Meng
;
Lin, Su-Qin
;
Wang, Ying
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/03/21
Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation
期刊论文
OAI收割
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2022, 卷号: 1867, 期号: 2, 页码: 13
作者:
Lu, Dasheng
;
Liu, Yameng
;
Luo, Yuhong
;
Zhao, Jie
;
Feng, Chao
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2022/01/18
Fatty acid oxidation
Acylcarnitines
FXR
FGF15/19
PGC1 alpha
Transcriptomics
Metabolomics
Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 43, 页码: 13
作者:
Tang, Xuehang
;
Ning, Mengmeng
;
Ye, Yangliang
;
Gu, Yipei
;
Yan, Hongyi
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/11/04
FXR agonist
Ketoxime ether
Target genes
Liver
blood ratio
Systemic activation