中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [11]
大连化学物理研究所 [6]
生物物理研究所 [1]
化学研究所 [1]
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OAI收割 [19]
内容类型
期刊论文 [17]
会议论文 [2]
发表日期
2022 [1]
2015 [1]
2014 [1]
2013 [2]
2012 [6]
2010 [3]
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学科主题
物理化学 [3]
Biochemica... [1]
Life Scien... [1]
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浏览/检索结果:
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Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 20, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Qingtong
;
Li, Yang
;
Chen, Li-Nan
;
Zhang, Zi-Chen
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/09/30
glucagon-like peptide-1 receptor
type 2 diabetes mellitus
cryoelectron microscopy
peptidomimetic agonism
Emergence of Chinese Drug Discovery Research: Impact of Hit and Lead Identification
期刊论文
OAI收割
JOURNAL OF BIOMOLECULAR SCREENING, 2015, 卷号: 20, 期号: 3, 页码: 318-329
作者:
Zhou, Caihong
;
Zhou, Yan
;
Wang, Jia
;
Zhu, Yue
;
Deng, Jiejie
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
review
drug discovery
hit identification
lead generation
compound library
Clozapine directly increases insulin and glucagon secretion from islets: Implications for impairment of glucose tolerance
期刊论文
OAI收割
SCHIZOPHRENIA RESEARCH, 2014, 卷号: 157, 期号: 1-3, 页码: 128-133
作者:
Smith, G. C.
;
Zhang, Z. Y.
;
Mulvey, T.
;
Petersend, N.
;
Lach, S.
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Clozapine
Diabetes
Insulin signalling
Schizophrenia
The role of serum albumin in the metabolism of Boc5: Molecular identification, species differences and contribution to plasma metabolism
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 卷号: 48, 期号: 1-2, 页码: 360-369
作者:
Ge, Guang-Bo
;
Ai, Chun-Zhi
;
Hu, Wen-Bing
;
Hou, Jie
;
Zhu, Liang-Liang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/04/09
Boc5
Albumin
Pseudo-esterase
Transesterification
Species Differences
The role of serum albumin in the metabolism of Boc5: Molecular identification, species differences and contribution to plasma metabolism
期刊论文
OAI收割
european journal of pharmaceutical sciences, 2013, 卷号: 48, 期号: 1-2, 页码: 360-369
作者:
Ge, Guang-Bo
;
Ai, Chun-Zhi
;
Hu, Wen-Bing
;
Hou, Jie
;
Zhu, Liang-Liang
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2014/09/11
Boc5
Albumin
Pseudo-esterase
Transesterification
Species differences
Dynamic monitoring of beta-cell injury with impedance and rescue by glucagon-like peptide-1
期刊论文
OAI收割
ANALYTICAL BIOCHEMISTRY, 2012, 卷号: 423, 期号: 1, 页码: 61-69
作者:
Guan, Ni
;
Gao, Weiwei
;
He, Min
;
Zheng, Min
;
Xu, Xiao
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
xCELLigence system
beta-Cell injury
Cytokines
Free fatty acids
Streptozotocin
Hydrogen peroxide
Glucagon-like peptide-1
Boc5
A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities
期刊论文
OAI收割
acta pharmacologica sinica, 2012, 卷号: 33, 期号: 2, 页码: 148-154
作者:
He, Min
;
Guan, Ni
;
Gao, Wei-wei
;
Liu, Qing
;
Wu, Xiao-yan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2015/11/13
type 2 diabetes
glucagon-like peptide-1
non-peptidic agonist
Boc5
G-protein coupled receptor
A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 2, 页码: 148-154
作者:
He, Min
;
Guan, Ni
;
Gao, Wei-wei
;
Liu, Qing
;
Wu, Xiao-yan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
type 2 diabetes
glucagon-like peptide-1
non-peptidic agonist
Boc5
G-protein coupled receptor
Determination of Boc5 in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study
期刊论文
OAI收割
CHROMATOGRAPHIA, 2012, 卷号: 75, 期号: 13-14, 页码: 721-727
Li, Ruixing
;
Fan, Huirong
;
Gu, Yuan
;
Si, Duanyun
;
Liang, Wei
;
梁伟
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2013/12/24
HPLC-MS/MS
Boc5
Nonpeptidic GLP-1R agonists
Pharmacokinetics
acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities
期刊论文
OAI收割
actapharmacologicasinica, 2012, 卷号: 33, 期号: 2, 页码: 148
作者:
He Min
;
Guan Ni
;
Gao Weiwei
;
Liu Qing
;
Wu Xiaoyan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/02