机构

• 上海药物研究所 [17]
• 昆明植物研究所 [4]
• 生态环境研究中心 [3]
• 力学研究所 [1]
• 南海海洋研究所 [1]
• 地理科学与资源研究所 [1]
• 更多

采集方式

• OAI收割 [32]

内容类型

• 期刊论文 [31]
• 学位论文 [1]

发表日期

• 2022 [3]
• 2021 [1]
• 2019 [3]
• 2018 [2]
• 2017 [2]
• 2016 [2]
• 更多

学科主题

• Plant Scie... [1]

筛选

浏览/检索结果: 共32条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238, 页码: 15 作者:  Zhu, Cheng-Liang;  Luo, Xiaomin;  Tian, Tian;  Rao, Zijian;  Wang, Hanlin   |  收藏  |  浏览/下载：28/0  |  提交时间：2022/08/16 AKT  Protein kinase B  PROTAC  Chemical degrader  Rational design   Evaluation of the Spatial Effect of Network Resilience in the Yangtze River Delta: An Integrated Framework for Regional Collaboration and Governance under Disruption 期刊论文  OAI收割 LAND, 2022, 卷号: 11, 期号: 8, 页码: 20 作者:  Che, Lei;  Xu, Jiangang;  Chen, Hong;  Sun, Dongqi;  Wang, Bao   |  收藏  |  浏览/下载：18/0  |  提交时间：2022/09/26 network resilience  interrupt simulation  spatial effect  regional governance  Yangtze River Delta region   Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235 作者:  Qu, Bingxue;  Xu, Yongjin;  Lu, Yang;  Zhuang, Weihao;  Jin, Xinxin   |  收藏  |  浏览/下载：24/0  |  提交时间：2022/12/23 XPO1  Multiple myeloma  MM.1S  N-phenylsulfonamide  Oral administration   Effect of Hypoxia on Photosystem II of Tropical Seagrass Enhalus acoroides in the Dark 期刊论文  OAI收割 PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2021, 页码: 8 作者:  Che, Xingkai;  Zhang, Tie;  Li, Hu;  Zhang, Litao;  Liu, Jianguo   |  收藏  |  浏览/下载：24/0  |  提交时间：2022/01/05 Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288 作者:  Dong, Xiaowu;  Zhan, Wenhu;  Zhao, Mengting;  Che, Jinxin;  Dai, Xiaoyang   |  收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01 Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文  OAI收割 TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83 作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan   |  收藏  |  浏览/下载：75/0  |  提交时间：2019/03/18 Acetyl-macrocalin B  Reactive oxygen species  p38 MAPK  Chk1/Chk2  Esophageal squamous cell carcinoma   Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 602-614 作者:  Dong, Xiao-Wu;  Zhang, Jian-Kang;  Xu, Lei;  Che, Jin-Xin;  Cheng, Gang   |  收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 Proteasome inhibitors  Tripeptide  Covalent docking  Interaction mode   Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125 作者:  Liu, Wenwen;  Wang, Huan;  Li, Xiaokang;  Xu, Yixiang;  Zhang, Jian   |  收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 Depression  Cognitive impairment  Multitarget-directed ligand  5-HT1A agonist  5-HT reuptake inhibition  ChE inhibition   Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents 期刊论文  OAI收割 ROYAL SOCIETY OPEN SCIENCE, 2018, 卷号: 5, 期号: 7 作者:  Che, Jinxin;  Wang, Zhilong;  Sheng, Haichao;  Huang, Feng;  Dong, Xiaowu   |  收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08 pharmacophore model  CXCR2  antagonists  anti-cancer metastasis   Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation 期刊论文  OAI收割 ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721 作者:  Li, Xiaokang;  Wang, Huan;  Xu, Yixiang;  Liu, Wenwen;  Gong, Qi   |  收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 Alzheimer's disease  depression  multitarget-directed ligand  ChE inhibition  5-HT1A agonist  5-HT reuptake inhibition