中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G
s
proteins
期刊论文
OAI收割
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 13
作者:
Cong, Zhaotong
;
Zhao, Fenghui
;
Li, Yang
;
Luo, Gan
;
Mai, Yiting
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/03/13
Nanobodies as negative allosteric modulators for human calcium sensing receptor
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 695, 页码: 9
作者:
Cui, Qianqian
;
Wang, Lu
;
Wang, Haonan
;
Chen, Xiaochen
;
Han, Li
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/04/09
G-protein-coupled receptor
Extracellular calcium sensing receptor
Nanobody
Cryo-electron microscope
Systemic Ca 2+homoeostasis
An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG
期刊论文
OAI收割
BMC BIOLOGY, 2024, 卷号: 22, 期号: 1, 页码: 14
作者:
Liu, Zhipei
;
Wang, Feng
;
Yuan, Hui
;
Tian, Fuyun
;
Yang, Chuanyan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/13
hERG
K525N
Gating Polarity
Voltage-Sensing Domain
LQT2
A novel phthalazinone derivative as a capsid assembly modulator inhibits hepatitis B virus expression
期刊论文
OAI收割
ANTIVIRAL RESEARCH, 2024, 卷号: 221, 页码: 14
作者:
Yang, Li
;
Gong, Ying
;
Liu, Feifei
;
Chen, Wuhong
;
Wang, Xinran
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/02/19
Hepatitis B virus
Capsid assembly
Phthalazinone derivatives
Apoptosis
Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 15
作者:
Kong, Linghui
;
Ning, Kuan
;
Liu, Xiao
;
Lu, Jiashuo
;
Chen, Baiyu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
N-cyclopropylmethyl nornepenthone derivatives
derivatives
Structure-activity relationship
MOR antagonist
Functional reversal
Reversal of subtype-selectivity
Opioid use disorder
Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 14
作者:
Li, Cuixia
;
Wu, Yiran
;
Wang, Wenli
;
Xu, Lu
;
Zhou, Yan
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17
A procedure for producing an anti-AXL nanobody in E. coli
期刊论文
OAI收割
PROTEIN EXPRESSION AND PURIFICATION, 2023, 卷号: 207, 页码: 106268
作者:
Lan, Zhongyun
;
Li, Lingyun
;
Sun, Yili
;
Meng, Xiangjing
;
Shi, Zhenzhong
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/27
AXL
Nanobody
Expression
Purification
Dirigent gene editing of gossypol enantiomers for toxicity-depleted cotton seeds
期刊论文
OAI收割
NATURE PLANTS, 2023, 卷号: 9, 期号: 4, 页码: 605-+
作者:
Lin, Jia-Ling
;
Fang, Xin
;
Li, Jian-Xu
;
Chen, Zhi-Wen
;
Wu, Wen-Kai
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/27
Engineering a HER2-CAR-NK Cell Secreting Soluble Programmed Cell Death Protein with Superior Antitumor Efficacy
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 7, 页码: 6843
作者:
Xia, Wenjiao
;
Chen, Jiaxin
;
Hou, Wenqing
;
Chen, Junsheng
;
Xiong, Ying
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/27
breast cancers
cytotherapy
chimeric antigen receptor
NK cells
sPD-1
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis
期刊论文
OAI收割
BIOACTIVE MATERIALS, 2022, 卷号: 17, 页码: 406-424
作者:
Wang, Jin
;
Xie, Si-an
;
Li, Ning
;
Zhang, Tao
;
Yao, Weijuan
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/06/10
Matrix stiffness
Inflammation
DDR1
DNMT1
Mechanotransduction