机构

• 上海药物研究所 [7]
• 合肥物质科学研究院 [2]

采集方式

• OAI收割 [9]

内容类型

• 期刊论文 [9]

发表日期

• 2023 [5]
• 2022 [2]
• 2021 [2]

学科主题

筛选

浏览/检索结果: 共9条，第1-9条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling 期刊论文  OAI收割 EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 卷号: 12, 期号: 1, 页码: 22 作者:  Wang, Yafang;  Yao, Mingyue;  Li, Cheng;  Yang, Kexin;  Qin, Xiaolong   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 KRAS(G12C)  c-Myc  PLK1  LncRNA  ST8SIA6-AS1  Drug resistance   From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead 期刊论文  OAI收割 GENES & DISEASES, 2023, 卷号: 10, 期号: 2, 页码: 403-414 作者:  Li, Hui-yu;  Qi, Wei-liang;  Wang, Yu-xiang;  Meng, Ling-hua   |  收藏  |  浏览/下载：117/0  |  提交时间：2023/10/17 Biomarkers  Covalent KRasG12Cinhibitors  Drug resistance  Human cancers  KRASG12Cmutation   Design, synthesis and biological evaluation of KRASG12C-PROTACs 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14 作者:  Zhang, Xiaoyi;  Zhao, Tong;  Sun, Minghao;  Li, Pei;  Lai, Mengzhen   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 KRASG12C  PROTAC  Covalent inhibitors  Structure-activity relationships (SARs)  Anticancer   Design, Synthesis, and Bioevaluation of Pyrido[2,3-d]pyrimidin-7-ones as Potent SOS1 Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2023, 页码: 183-190 作者:  Liu, Meiying;  Zhou, Guizhen;  Su, Wenhong;  Gu, Yuejiao;  Gao, Mingshan   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/03/27 KRAS mutation  SOS1-KRAS interaction  SOS1 inhibitor  combination therapy   Targeting PI3K alpha overcomes resistance to KRas(G12C) inhibitors mediated by activation of EGFR and/or IGF1R 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 12 作者:  Qi, Wei-liang;  Li, Hui-yu;  Wang, Yi;  Xu, Lan;  Deng, Jie-ting   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/04/10 AMG510  KRas(G12C)  PI3K  drug resistance  combination therapy   Safety and Efficacy of D-1553 in Patients with KRAS G12C Mutated Non-Small Cell Lung Cancer: A Phase 1 Trial 期刊论文  OAI收割 JOURNAL OF THORACIC ONCOLOGY, 2022, 卷号: 17 作者:  Lu, S.;  Jian, H.;  Zhang, Y.;  Song, Z.;  Zhao, Y.   |  收藏  |  浏览/下载：22/0  |  提交时间：2022/12/23 Non-small cell lung cancer  KRAS G12C mutation  Small molecular inhibitor   KRAS-Mutant Non-Small Cell Lung Cancer: An Emerging Promisingly Treatable Subgroup 期刊论文  OAI收割 FRONTIERS IN ONCOLOGY, 2021, 卷号: 11 作者:  Xie, Mingying;  Xu, Xiaoling;  Fan, Yun   |  收藏  |  浏览/下载：36/0  |  提交时间：2021/06/15 KRAS-mutant  NSCLC  targeted therapy  immunotherapy  AMG510  MRTX849   Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS(G12C) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 213, 页码: 17 作者:     |  收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24 KRAS  Covalent inhibitor  Pyridopyrimidinone  Antiproliferative effect  Scaffold hopping