中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [72]
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期刊论文 [259]
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浏览/检索结果:
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Structure-Activity Relationships of 2-(Arylthio)benzoic Acid FTO Inhibitors
期刊论文
OAI收割
ISRAEL JOURNAL OF CHEMISTRY, 2024, 页码: 13
作者:
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/03/25
RNA modification
m(6)A
FTO
anticancer
Targeting ST8SIA6-AS1 counteracts KRAS
G12C
inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 卷号: 12, 期号: 1, 页码: 22
作者:
Wang, Yafang
;
Yao, Mingyue
;
Li, Cheng
;
Yang, Kexin
;
Qin, Xiaolong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/26
KRAS(G12C)
c-Myc
PLK1
LncRNA
ST8SIA6-AS1
Drug resistance
Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 18
作者:
Zhang, Jingyu
;
Duan, Haiting
;
Gui, Renzhao
;
Wu, Mingfei
;
Shen, Liteng
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/19
Acute myeloid leukemia
Bromodomain-containing protein 9
Proteolysis-targeting chimera
Orally bioavailable
Docking
Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1
期刊论文
OAI收割
RSC MEDICINAL CHEMISTRY, 2023, 页码: 14
作者:
Deng, Minjie
;
Gao, Yue
;
Wang, Peipei
;
Du, Wenjing
;
Xu, Gaoya
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/02/19
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
;
Zhan, Zhengsheng
;
Kang, Zhuang
;
Li, Mengyuan
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably
Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 17
作者:
Zhang, Ranran
;
Wang, Pengyu
;
Wei, Bingyan
;
Chen, Liang
;
Song, Xiaomin
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/10/17
ClpP agonists
Structure-activity relationship
Mitochondrial respiratory chain
Antileukemic therapy
Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment
期刊论文
OAI收割
JOURNAL OF NANOBIOTECHNOLOGY, 2023, 卷号: 21
作者:
Qingxin, Song
;
Kai, Jiang
;
Dandan, Zheng
;
Linyu, Jin
;
Xiuyuan, Chen
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/11/10
Intervertebral disc degeneration
Gene therapy
DNA hydrogel
Autophagy
Extracellular matrix
Breaking Tumor Immunosuppressive Network by Regulating Multiple Nodes with Triadic Drug Delivery Nanoparticles
期刊论文
OAI收割
ACS NANO, 2023, 卷号: 17, 期号: 18, 页码: 17826-17844
作者:
Yan, Wenlu
;
Li, Yu
;
Zou, Yiting
;
Zhu, Runqi
;
Wu, Ting
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
triple-negative breast cancer
antitumor immunity
tumor-associated macrophages
myeloid-derived suppressorcells
immune network
nanoparticle
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy
期刊论文
OAI收割
CANCER CELL, 2023, 卷号: 41, 期号: 7, 页码: 1294-+
作者:
Wang, Liangliang
;
Dou, Xiaoyang
;
Chen, Shijie
;
Yu, Xianbin
;
Huang, Xiaona
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 22
作者:
Xiao, Pan
;
Duan, Zongliang
;
Liu, Zeyu
;
Chen, Liang
;
Zhang, Deyan
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/17