机构

• 上海药物研究所 [38]
• 广州生物医药与健康研... [6]
• 新疆理化技术研究所 [1]
• 大连化学物理研究所 [1]
• 昆明植物研究所 [1]
• 上海有机化学研究所 [1]
• 更多

采集方式

• OAI收割 [48]

内容类型

• 期刊论文 [48]

发表日期

• 2024 [2]
• 2023 [4]
• 2022 [5]
• 2021 [7]
• 2020 [1]
• 2018 [4]
• 更多

学科主题

• Pharmacolo... [6]
• 生命有机化学 [1]

筛选

浏览/检索结果: 共48条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design   Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 18 作者:  Zhang, Jingyu;  Duan, Haiting;  Gui, Renzhao;  Wu, Mingfei;  Shen, Liteng   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/12/19 Acute myeloid leukemia  Bromodomain-containing protein 9  Proteolysis-targeting chimera  Orally bioavailable  Docking   Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15 作者:  Jiang, Xiangrui;  Su, Haixia;  Shang, Weijuan;  Zhou, Feng;  Zhang, Yan   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 253, 页码: 16 作者:  He, Yulong;  Li, Shunyi;  Zhu, Yueyue;  Wang, Yujie;  Chen, Yuqi   |  收藏  |  浏览/下载：62/0  |  提交时间：2023/10/17 Structure-activity relationship  FABP4 inhibitor  Biphenyl scaffold  Selectivity  Oral bioavailability  Anti-inflammation   Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 4, 页码: 2608-2621 作者:  Wang, Jingyao;  Zhou, Shaoqing;  Cheng, Yan;  Cheng, Lin;  Qin, Ying   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/03/27 Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15 作者:  Zhan, Zhengsheng;  Ji, Yinchun;  Su, Haixia;  Fang, Chen;  Peng, Xia   |  收藏  |  浏览/下载：30/0  |  提交时间：2023/04/10 Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 29 作者:  Huang, Jindi;  Chen, Liye;  Wu, Jiangxia;  Ai, Daiqiao;  Zhang, Ji-Quan   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/04/10 Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 22, 页码: 15374-15390 作者:  Chan, Shingpan;  Zhang, Yunong;  Wang, Jie;  Yu, Qiuchun;  Peng, Xia   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/04/10 Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 13, 页码: 9096–9125 作者:  Zhang, Jingyu;  Che, Jinxin;  Luo, Xiaomin   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/03/21