中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [7]
上海应用物理研究所 [3]
合肥物质科学研究院 [2]
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大连化学物理研究所 [1]
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OAI收割 [17]
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期刊论文 [16]
会议论文 [1]
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A robust and validated LC-MS/MS method for the quantification of ramucirumab in rat and human serum using direct enzymatic digestion without immunoassay
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2024, 卷号: 1234, 页码: 11
作者:
Huang, Wen-si
;
Li, Wei-qiang
;
Yu, Xiong
;
Xue, Ming-zhen
;
Yuan, Ya-li
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/04/09
Anti -gastric cancer monoclonal antibody
Ramucirumab
LC -MS/MS
Method validation
Surrogate peptide
A validated LC-MS/MS method for the quantification of bevacizumab in rat, cynomolgus monkey, and human serum
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 235, 页码: 11
作者:
Zhou, Ainan
;
Yu, Jinghua
;
Wu, Yali
;
Xue, Hao
;
Zhong, Dafang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Monoclonal antibody
Bevacizumab
LC-MS
MS
Surrogate peptide
Pharmacokinetics
Serum
Development and validation of a LC-MS/MS method for quantitation of recombinant human growth hormone in rat plasma and application to a pharmacokinetic study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 224, 页码: 9
作者:
Huang, Wen-si
;
Yu, Jing-hua
;
Diao, Xing-xing
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/04/10
Recombinant human growth hormone (rhGH)
Somatotropin
Method validation
LC-MS
MS
Pharmacokinetics
Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2021, 卷号: 11, 期号: 4, 页码: 472-479
作者:
Gao, Yuxiong
;
Chen, Zhendong
;
Yang, Changyong
;
Zhong, Dafang
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/11/04
Anti-sclerostin monoclonal antibody (SHR-1222)
LC-MS/MS
Anti-drug antibody
Toxicokinetic
Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond
期刊论文
OAI收割
CHEMICAL SCIENCE, 2020, 卷号: 11
作者:
Zhao, Rui
;
Shi, Pan
;
Chen, Junyou
;
Sun, Shuaishuai
;
Chen, Jingnan
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/10/26
Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 卷号: 59
作者:
Qu, Qian
;
Gao, Shuai
;
Wu, Fangming
;
Zhang, Meng-Ge
;
Li, Ying
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/11/26
chemical protein synthesis
cyclic peptides
disulfides
native chemical ligation
peptides
Fluorine-18 click radiosynthesis and microPET/CT evaluation of a small peptide-a potential PET probe for carbonic anhydrase IX
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 5, 页码: 785—789
作者:
Jia, LN
;
Li, X
;
Cheng, DF
;
Zhang, L
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/12/30
RENAL-CELL CARCINOMA
IN-VIVO
CA-IX
BIOLOGICAL EVALUATION
TUMOR HYPOXIA
POOR-PROGNOSIS
BREAST-CANCER
EXPRESSION
MARKER
INHIBITION
Guiding protein delivery into live cells using DNA-programmed membrane fusion
期刊论文
OAI收割
CHEMICAL SCIENCE, 2018, 卷号: 9, 期号: 27, 页码: 5967-5975
作者:
Sun, LL
;
Gao, YJ
;
Wang, YG
;
Wei, Q
;
Shi, JY
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/17
EFFICIENT INTRACELLULAR DELIVERY
HYBRIDIZATION CHAIN-REACTION
LIPID-ANCHORED DNA
DRUG-DELIVERY
IN-VITRO
LIPOSOMES
PEPTIDE
RELEASE
POLYMER
SURFACE
OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1359-1369
作者:
Ma, Shan-yao
;
Ning, Meng-meng
;
Zou, Qing-an
;
Feng, Ying
;
Ye, Yang-liang
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
OL3
MN6
linagliptin
TGR5 agonist
DPP4 inhibitor
GLP-1
low-absorbed
gallbladder filling
type 2 diabetes mellitus