机构

• 上海药物研究所 [10]

采集方式

• OAI收割 [10]

内容类型

• 期刊论文 [9]
• 会议论文 [1]

发表日期

• 2024 [1]
• 2023 [1]
• 2021 [1]
• 2019 [1]
• 2016 [4]
• 2015 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共10条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18 作者:  Zhuo, Ning;  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Yin, Jianpeng   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/25 Type 2 Diabetes  TGR5 agonist  Betulinic acid  Gut-restricted  Gallbladder-filling effects  Kinetophores   TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 8, 页码: 1649-1664 作者:  Yang, Wen-ji;  Han, Fang-hui;  Gu, Yi-pei;  Qu, Hui;  Liu, Jia   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27 TGR5 agonist  ulcerative colitis  intestinal epithelial cell  apoptosis  cAMP  PKA signaling pathway  c-FLIP   Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12181-12199 作者:  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Liang, Xiaoying;  Lan, Yuan   |  收藏  |  浏览/下载：42/0  |  提交时间：2021/11/04 TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice 期刊论文  OAI收割 METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 卷号: 99, 页码: 45-56 作者:  Huang, Suling;  Ma, Shanyao;  Ning, Mengmeng;  Yang, Wenji;  Ye, Yangliang   |  收藏  |  浏览/下载：30/0  |  提交时间：2020/07/01 TGR5  Glucose homeostasis  Insulin resistance  Skeletal muscle  Type 2 diabetes   OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1359-1369 作者:  Ma, Shan-yao;  Ning, Meng-meng;  Zou, Qing-an;  Feng, Ying;  Ye, Yang-liang   |  收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 OL3  MN6  linagliptin  TGR5 agonist  DPP4 inhibitor  GLP-1  low-absorbed  gallbladder filling  type 2 diabetes mellitus   Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect 期刊论文  OAI收割 SCIENTIFIC REPORTS, 2016, 卷号: 6 作者:  Cao, Hua;  Chen, Zhi-Xiang;  Wang, Kai;  Ning, Meng-Meng;  Zou, Qing-An   |  收藏  |  浏览/下载：12/0  |  提交时间：2019/01/08 Discovery and Structure-Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists 期刊论文  OAI收割 CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 卷号: 64, 期号: 4, 页码: 326-339 作者:  Chen, Zhixiang;  Ning, Mengmeng;  Zou, Qingan;  Cao, Hua;  Ye, Yangliang   |  收藏  |  浏览/下载：9/0  |  提交时间：2019/01/08 Takeda G-protein-coupled receptor 5 agonist  bioisostere  microsomal clearance  structure-activity relationship   ol3anovellowabsorbedtgr5agonistwithreducedsideeffectsloweredbloodglucoseviadualactionsontgr5activationanddpp4inhibition 期刊论文  OAI收割 actapharmacologicasinica, 2016, 卷号: 000, 期号: 010, 页码: 1359 作者:  Ma Shanyao;  Ning Mengmeng;  Zou Qingan;  Feng Ying;  Ye Yangliang   |  收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01 OL3  MN6  linagliptin  TGR5 agonist  DPP4 inhibitor  GLP-1  low-absorbed  gallbladder filling  type 2 diabetes mellitus   Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 58, 期号: 8, 页码: 3315-3328 作者:  Duan, Hongliang;  Ning, Mengmeng;  Zou, Qingan;  Ye, Yangliang;  Feng, Ying   |  收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08 Structure-activity relationship study of betulinic acid as TGR5 agonist 会议论文  OAI收割 作者:  Wang, Xiaoyin   |  收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08