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浏览/检索结果: 共653条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Understanding the spatial heterogeneity of grazing pressure in the Three-River-Source Region on the Tibetan Plateau 期刊论文  OAI收割 JOURNAL OF GEOGRAPHICAL SCIENCES, 2023, 卷号: 33, 期号: 8, 页码: 1660-1680 作者:  Gu, Changjun;  Liu, Linshan;  Zhang, Yili;  Wei, Bo;  Cui, Bohao   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/09/07 grazing intensity  GPS-tracking  spatial heterogeneity  yak  Tibetan Plateau   TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 8, 页码: 1649-1664 作者:  Yang, Wen-ji;  Han, Fang-hui;  Gu, Yi-pei;  Qu, Hui;  Liu, Jia   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27 TGR5 agonist  ulcerative colitis  intestinal epithelial cell  apoptosis  cAMP  PKA signaling pathway  c-FLIP   Integrated application of transcriptomics and metabolomics provides insights into acute hepatopancreatic necrosis disease resistance of Pacific white shrimp Litopenaeus vannamei 期刊论文  OAI收割 MSYSTEMS, 2023, 页码: 20 作者:  Sun, Mingzhe;  Yu, Yang;  Li, Shihao;  Liu, Yuan;  Zhang, Xiaojun   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/12/13 Litopenaeus vannamei  acute hepatopancreatic necrosis disease  disease resistance  transcriptome  metabolome   Discovery of Novel 5,6-Dihydro-1,2,4-triazine Derivatives as Efficacious Glucagon-Like Peptide-1 Receptor Agonists 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23 作者:  Chen, Lili;  Yun, Ying;  Guo, Shimeng;  Wang, Xiaoyan;  Xiong, Muya   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 The ketone body acetoacetate activates human neutrophils through FFAR2 期刊论文  OAI收割 JOURNAL OF LEUKOCYTE BIOLOGY, 2023, 卷号: 113, 期号: 6, 页码: 577-587 作者:  Martensson, Jonas;  Bjorkman, Lena;  Lind, Simon;  Viklund, Moa Bjerhem;  Zhang, Linjie   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 acetoacetate  FFAR2  G-protein coupled receptor  ketone body  neutrophil   Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 18, 页码: 11 作者:  Xu, Haiyu;  Li, Shufen;  Liu, Jiayuan;  Cheng, Jinlong;  Kang, Liping   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/10/17 COVID-19  traditional Chinese medicine  TCMT-NDRD  antivirus  anti-inflammation   Anxiolytic-like effect of Suanzaoren-Wuweizi herb-pair and evidence for the involvement of the monoaminergic system in mice based on network pharmacology 期刊论文  OAI收割 BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2023, 卷号: 23, 期号: 1, 页码: 17 作者:  Liu, Jie;  Shi, Jin-Li;  Guo, Jian-You;  Chen, Yi;  Ma, Xiao-Jie   |  收藏  |  浏览/下载：40/0  |  提交时间：2023/03/01 Suanzaoren-Wuweizi  Anxiolytic-like effect  Mechanism  Monoaminergic system  Network pharmacology   The Agonist of Adenosine A1 Receptor Induced Desensitization of delta Opioid receptor-mediated Raf-1/MEK/ERK Signaling by Feedback Phosphorylation of Raf-1-Ser289/296/301 期刊论文  OAI收割 NEUROCHEMICAL RESEARCH, 2022, 页码: 12 作者:  Xu, Chi;  Cheng, Yun;  Han, Manman;  Tao, Yimin;  Liu, Jing-Gen   |  收藏  |  浏览/下载：17/0  |  提交时间：2023/04/10 Adenosine A1 receptor  N6-cyclohexyladenosine  Delta opioid receptor  Raf-1  Desensitization   Hepatic Sam68 Regulates Systemic Glucose Homeostasis and Insulin Sensitivity 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 卷号: 23, 期号: 19, 页码: 14 作者:  Qiao, Aijun;  Ma, Wenxia;  Jiang, Ying;  Han, Chaoshan;  Yan, Baolong   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/11/11 Sam68  hepatocytes  gluconeogenesis  high-fat diet  diabetes  CRTC2  insulin sensitivity  glucagon  glucose metabolism  protein-protein interaction