机构

• 上海药物研究所 [11]

采集方式

• OAI收割 [11]

内容类型

• 期刊论文 [11]

发表日期

• 2021 [11]

学科主题

筛选

浏览/检索结果: 共11条，第1-10条 帮助 限定条件 发表日期：2021     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14822-14847 作者:  Wei, Dan;  Wang, Hanlin;  Zeng, Qinghe;  Wang, Wenjing;  Hao, Bingbing   |  收藏  |  浏览/下载：45/0  |  提交时间：2021/12/16 Discovery of High-Affinity Inhibitors of the BPTF Bromodomain 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12075-12088 作者:  Lu, Tian;  Lu, Haibo;  Duan, Zhe;  Wang, Jun;  Han, Jie   |  收藏  |  浏览/下载：43/0  |  提交时间：2021/11/04 Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution 期刊论文  OAI收割 CELL REPORTS, 2021, 卷号: 36, 期号: 4, 页码: 22 作者:  Gao, Mengqing;  Wang, Jin;  Rousseaux, Sophie;  Tan, Minjia;  Pan, Lulu   |  收藏  |  浏览/下载：52/0  |  提交时间：2021/11/04 Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14 作者:  Yang, Xiangbo;  Wang, Zhijia;  Pei, Yuan;  Song, Ning;  Xu, Lei   |  收藏  |  浏览/下载：28/0  |  提交时间：2021/08/17 SHP2 degradation  Proteolysis targeting chimera (PROTAC)  Thalidomide-based heterobifunctional molecules  E3 ubiquitin ligase  CRBN   Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum 期刊论文  OAI收割 FITOTERAPIA, 2021, 卷号: 151, 页码: 4 作者:  Yang, Fan;  Hua, Qiang;  Yao, Li-Gong;  Liang, Lin-Fu;  Lu, Yan-Hua   |  收藏  |  浏览/下载：32/0  |  提交时间：2021/08/17 Soft coral  Litophyton nigrum  Nardosinane   Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells 期刊论文  OAI收割 GENOMICS, 2021, 卷号: 113, 期号: 3, 页码: 1057-1069 作者:  Liu, Yuwei;  Xue, Mengzhu;  Cao, Danyan;  Qin, Lihuai;  Wang, Ying   |  收藏  |  浏览/下载：25/0  |  提交时间：2021/08/17 Multi-omics  BET inhibitor responses  WNT pathway  Liver cancer  Precise therapy   Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 185, 页码: 14 作者:  Wu, Qian;  Chen, Dan-Qi;  Sun, Lin;  Huan, Xia-Juan;  Bao, Xu-Bin   |  收藏  |  浏览/下载：39/0  |  提交时间：2021/05/24 N2817  Bivalent BET inhibitors  Monovalent BET inhibitors  TAF1  Anticancer activity   Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 18 作者:  Bernasocchi, Tiziano;  El Tekle, Geniver;  Bolis, Marco;  Mutti, Azzurra;  Vallerga, Arianna   |  收藏  |  浏览/下载：20/0  |  提交时间：2021/05/24 Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504 作者:  Liu, Xiaohua;  Zhang, Yu;  Li, Yalei;  Wang, Juan;  Ding, Huaqian   |  收藏  |  浏览/下载：20/0  |  提交时间：2021/05/24 Medulloblastoma  Hedgehog signaling  pathway  Drug resistance  GLI  BRD4   Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer 期刊论文  OAI收割 NANO TODAY, 2021, 卷号: 36, 页码: 12 作者:  Zhou, Fengqi;  Gao, Jing;  Xu, Zhiai;  Li, Tianliang;  Gao, Ang   |  收藏  |  浏览/下载：28/0  |  提交时间：2021/06/11 Tumor microenvironment  Prodrug nanovesicles  Cancer immunotherapy  Immunogenic cell death  Adaptive immune resistance