中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [96]
合肥物质科学研究院 [20]
昆明植物研究所 [13]
西北高原生物研究所 [7]
海洋研究所 [6]
广州能源研究所 [4]
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OAI收割 [155]
内容类型
期刊论文 [151]
学位论文 [4]
发表日期
2021 [155]
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An overview of kinase downregulators and recent advances in discovery approaches
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:
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收藏
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浏览/下载:63/0
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提交时间:2022/01/25
Macrocephatriolides A and B: Two Guaianolide Trimers from Ainsliaea macrocephala as PTP1B Inhibitors and Insulin Sensitizers
期刊论文
OAI收割
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 24, 页码: 17782-17789
作者:
Ren, Yong-Mei
;
Zhang, Rui
;
Feng, Zheling
;
Ke, Chang-Qiang
;
Yao, Sheng
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收藏
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浏览/下载:25/0
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提交时间:2022/06/15
Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
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收藏
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浏览/下载:28/0
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提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
OAI收割
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:87/0
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提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Nanopore detects.-radiation inhibited HIV-1 protease activity
期刊论文
OAI收割
BIOSENSORS & BIOELECTRONICS, 2021, 卷号: 194, 页码: 5
作者:
Li, Minghan
;
Li, Wei
;
Xiao, Yicen
;
Liu, Qianshan
;
Liang, Liyuan
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收藏
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浏览/下载:66/0
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提交时间:2021/11/26
HIV-1 protease
GagPol precursor
Enzyme inactivation
Co-60 gamma-radiation
Nanopore
Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 52, 页码: 12
作者:
Ding, Hong
;
Pei, Yuan
;
Li, Yuanqing
;
Xu, Wen
;
Mei, Lianghe
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收藏
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浏览/下载:37/0
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提交时间:2022/06/15
Epigenetics
Histone acetyltransferase
P300/CBP
Ovarian cancer
A nomogram model based on peripheral blood lymphocyte subsets to assess the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors
期刊论文
OAI收割
TRANSLATIONAL LUNG CANCER RESEARCH, 2021
作者:
Xu, Xiaoling
;
Wang, Ding
;
Chen, Wei
;
Li, Na
;
Suwinski, Rafal
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收藏
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浏览/下载:75/0
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提交时间:2022/02/14
Immune checkpoint inhibitor (ICI)
non-small cell lung cancer (NSCLC)
peripheral blood lymphocyte subsets
FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021
作者:
Yin, Yan-ping
;
Ma, Li-ying
;
Cao, Guo-zhen
;
Hua, Jing-han
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收藏
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浏览/下载:31/0
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提交时间:2022/01/10
small cell lung cancer
topotecan
DNA damage response
FK228
SLFN11
methylation
epigenetic modulation
Transcriptomic Response to Perkinsus marinus in Two Crassostrea Oysters Reveals Evolutionary Dynamics of Host-Parasite Interactions
期刊论文
OAI收割
FRONTIERS IN GENETICS, 2021, 卷号: 12, 页码: 16
作者:
Chan, Jiulin
;
Wang, Lu
;
Li, Li
;
Mu, Kang
;
Bushek, David
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收藏
  |  
浏览/下载:51/0
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提交时间:2022/04/12
oyster
comparative transcriptomics
dermo disease
innate immune response
host-parasite
interaction
gene expansion
adaptation
Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
OAI收割
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
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收藏
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浏览/下载:47/0
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提交时间:2022/01/18