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Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD 期刊论文  OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 96, 页码: 12
作者:  Song, Zhaoxiang;  Lu, Dan;  Sun, Jun;  Ye, Yangliang;  Fang, Jiahui
  |  收藏  |  浏览/下载：26/0  |  提交时间：2024/01/16
GPR35  IBD  Lodoxamide  
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects 期刊论文  OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:  Yang, Xin-Mei;  Yang, Yang;  Yao, Bu-Fan;  Ye, Pan-Pan;  Xu, Yan
  |  收藏  |  浏览/下载：11/0  |  提交时间：2023/12/11
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong
  |  收藏  |  浏览/下载：9/0  |  提交时间：2024/01/26
Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease 期刊论文  OAI收割
CARBOHYDRATE POLYMERS, 2023, 卷号: 316, 页码: 15
作者:  Jing, Shisuo;  Chen, Huayuan;  Liu, Ergang;  Zhang, Meng;  Shen, Huan
  |  收藏  |  浏览/下载：89/0  |  提交时间：2023/10/17
Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for Treatment of Nectin-4-expressing Cancers 期刊论文  OAI收割
MOLECULAR CANCER THERAPEUTICS, 2023, 卷号: 22, 期号: 8, 页码: 913-925
作者:  Zhou, Wei;  Fang, Peng;  Yu, Dongan;  Ren, Hongyuan;  You, Meng
  |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17
TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 8, 页码: 1649-1664
作者:  Yang, Wen-ji;  Han, Fang-hui;  Gu, Yi-pei;  Qu, Hui;  Liu, Jia
  |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27
Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12
作者:  Yu, Lei;  Wang, Ya-fang;  Xiao, Jian;  Shen, Qian-qian;  Chi, Shuai-shuai
  |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17
Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression 期刊论文  OAI收割
Signal Transduction and Targeted Therapy, 2023, 卷号: 8, 期号: 2, 页码: 692-704
作者:  Hu, Zonglong;  Wei, Fan;  Su, Yi;  Wang, Yafang;  Shen, Yanyan
  |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/27
ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK 期刊论文  OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 9
作者:  Song, Peiran;  Bai, Gang;  Chan, Shingpan;  Zhang, Tao;  Tong, Linjiang
  |  收藏  |  浏览/下载：27/0  |  提交时间：2023/04/10
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism 期刊论文  OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 16
作者:  Yan, Ying;  Niu, Zhoumin;  Sun, Chao;  Li, Peng;  Shen, Siyi
  |  收藏  |  浏览/下载：28/0  |  提交时间：2022/12/13