机构

• 上海药物研究所 [87]

采集方式

• OAI收割 [87]

内容类型

• 期刊论文 [87]

发表日期

• 2024 [1]
• 2023 [18]
• 2022 [12]
• 2021 [10]
• 2020 [8]
• 2019 [6]
• 更多

学科主题

• Chemistry [1]
• Pharmacolo... [1]

筛选

浏览/检索结果: 共87条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects 期刊论文  OAI收割 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9 作者:  Yang, Xin-Mei;  Yang, Yang;  Yao, Bu-Fan;  Ye, Pan-Pan;  Xu, Yan   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/12/11 COVID-19  Simnotrelvir  Safety  Pharmacokinetics  Healthy subjects   Indole-3-Propionic Acid, a Gut Microbiota Metabolite, Protects Against the Development of Postoperative Delirium 期刊论文  OAI收割 ANNALS OF SURGERY, 2023, 卷号: 278, 期号: 6, 页码: E1164-E1174 作者:  Zhou, Xue;  Wu, Xinbo;  Wu, Yan;  Yang, Liuyue;  Shi, Eleanor   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/04/09 gut microbiota  indole-3-propionic acid  anesthesia  surgery  postoperative delirium   Development of PI3Kγ selective inhibitors: the strategies and application 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 10 作者:  Gu, Dong-Yan;  Zhang, Meng-Meng;  Li, Jia;  Zhou, Yu-Bo;  Sheng, Rong   |  收藏  |  浏览/下载：4/0  |  提交时间：2023/12/08 PI3K  PI3K gamma inhibitors  isoform selectivity  drug development  rational drug design   Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons 期刊论文  OAI收割 MOLECULAR PSYCHIATRY, 2023, 页码: 11 作者:  Zhang, Yong-mei;  Zong, Hai-chao;  Qi, Ying-bei;  Chang, Liu-liu;  Gao, Ya-nan   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/12/08 Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2023, 卷号: 215, 页码: 14 作者:  Xu, Zhuo;  Wang, Hui;  Meng, Qian;  Ding, Yiluan;  Zhu, Mengying   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 Otilonium Bromide  Deubiquitinase  USP28  Selective inhibitor   Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes 期刊论文  OAI收割 JOURNAL OF STRUCTURAL BIOLOGY, 2023, 卷号: 215, 期号: 3, 页码: 9 作者:  Sun, Zengchao;  Wang, Lu;  Li, Lingyun;  Sun, Yili;  Zhang, Daizhou   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 SARS-CoV-2 virus  Receptor -binding domain  Nanobody  Crystal structure  Conservative binding epitope  Bi-paratopic nanobodies   Intercellular genetic tracing of cardiac endothelium in the developing heart 期刊论文  OAI收割 DEVELOPMENTAL CELL, 2023, 卷号: 58, 期号: 16, 页码: 1502-+ 作者:  Liu, Kuo;  Jin, Hengwei;  Zhang, Shaohua;  Tang, Muxue;  Meng, Xinfeng   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/10/17 Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for Treatment of Nectin-4-expressing Cancers 期刊论文  OAI收割 MOLECULAR CANCER THERAPEUTICS, 2023, 卷号: 22, 期号: 8, 页码: 913-925 作者:  Zhou, Wei;  Fang, Peng;  Yu, Dongan;  Ren, Hongyuan;  You, Meng   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 Preparation and characterization of nanobodies targeting SARS-CoV-2 papain-like protease 期刊论文  OAI收割 PROTEIN EXPRESSION AND PURIFICATION, 2023, 卷号: 207, 页码: 106267 作者:  Qiao, Huarui;  Li, Lingyun;  Wang, Lu;  Yu, Haijun;  Hu, Fangzheng   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/03/27 SARS-CoV-2  Papain like protease (PLpro)  Nanobody  PLpro inhibitor