中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [28]
合肥物质科学研究院 [8]
大连化学物理研究所 [7]
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期刊论文 [79]
会议论文 [4]
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2024 [2]
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Chemistry [1]
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Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-KB-inducing kinase (NIK)
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1295, 页码: 19
作者:
Cheng, Jing
;
Yan, Ziqin
;
Li, Xinzhi
;
Liu, Chen
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
Kinase inhibitor
NIK
NF-KB2
Indoline
COT
Cytotoxicity
Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1079-1092
作者:
Qin, Shaozhao
;
Feng, Lijian
;
Zhao, Qingyi
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/02/27
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:
Cheng, Jing
;
Yan, Ziqin
;
Jiang, Kailong
;
Liu, Chen
;
Xu, Dehua
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/02/19
Design, Construction, and Screening of Diversified Pyrimidine-Focused DNA-Encoded Libraries
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 14, 期号: 8, 页码: 1073-1078
作者:
Seydimemet, Mengnisa
;
Yang, Yixuan
;
Lv, Yuhan
;
Liu, Jiaxiang
;
Yan, Ziqin
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17
DNA-encoded library technology
Pyrimidine-focusedDNA-encodedlibrary
BRD4
Affinity screening
Inhibitor
Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 17
作者:
Yan, Ziqin
;
Lyu, Xilin
;
Lin, Dongze
;
Wu, Gaoxing
;
Gong, Yang
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/17
VideoFusion: Decomposed Diffusion Models for High-Quality Video Generation
会议论文
OAI收割
加拿大温和华, 2023-6
作者:
Luo, Zhengxiong
;
Chen, Dayou
;
Zhang, Yingya
;
Huang, Yan
;
Wang, Liang
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/06/09
Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 871, 页码: 13
作者:
Zhao, Xiaoran
;
Wang, Qing
;
Li, Xiangfei
;
Xu, Hua
;
Ren, Chuanbo
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/11/15
Progestin
Histology
Transcriptome
Metabolome
Bivalve
Synthesis and Biological Evaluation of Sclareolide-Indole Conjugates and Their Derivatives
期刊论文
OAI收割
MOLECULES, 2023, 卷号: 28, 期号: 4, 页码: 1737
作者:
Cheng, Ying
;
Lyu, Xilin
;
Liu, Chen
;
Wang, Xiancheng
;
Cheng, Jing
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/27
sclareolide
indole
polyphenol
acetal
antitumor activity
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 1, 页码: 157-173
作者:
Sun, Mingming
;
Li, Leilei
;
Niu, Yujia
;
Wang, Yingzhi
;
Yan, Qi
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/27
Lung cancer
Metabolic reprogramming
Post-translational modification
PRMT6
Pentose phosphate pathway flux
Glycolysis
6-Phospho-gluconate dehydrogenase
a-enolase
ENO1
A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243, 页码: 31
作者:
Lou, Jianfeng
;
Lu, Yuhang
;
Cheng, Jing
;
Zhou, Feilong
;
Yan, Ziqin
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/12/13
TEAD
YAP
Palmitoylation
Protein-protein interaction
Covalent inhibitor