中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [96]
采集方式
OAI收割 [96]
内容类型
期刊论文 [96]
发表日期
2021 [96]
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共96条,第1-10条
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发表日期:2021
内容类型:期刊论文
专题:上海药物研究所
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Macrocephatriolides A and B: Two Guaianolide Trimers from Ainsliaea macrocephala as PTP1B Inhibitors and Insulin Sensitizers
期刊论文
OAI收割
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 24, 页码: 17782-17789
作者:
Ren, Yong-Mei
;
Zhang, Rui
;
Feng, Zheling
;
Ke, Chang-Qiang
;
Yao, Sheng
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/06/15
Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
OAI收割
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 52, 页码: 12
作者:
Ding, Hong
;
Pei, Yuan
;
Li, Yuanqing
;
Xu, Wen
;
Mei, Lianghe
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/06/15
Epigenetics
Histone acetyltransferase
P300/CBP
Ovarian cancer
Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
OAI收割
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2022/01/18
Design, Synthesis, and Biological Evaluation of HDAC Degraders with CRBN E3 Ligase Ligands
期刊论文
OAI收割
MOLECULES, 2021, 卷号: 26, 期号: 23, 页码: 19
作者:
Lu, Yingxin
;
Sun, Danwen
;
Xiao, Donghuai
;
Shao, Yingying
;
Su, Mingbo
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/06/15
HDAC degraders
CRBN ligands
proteins of interest
benzyl alcohol linkage
Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 22, 页码: 16650-16674
作者:
Zhang, Zhuqing
;
Guo, Zuhao
;
Xu, Xiaowei
;
Cao, Danyan
;
Yang, Hong
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/06/15
Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 22, 页码: 16687-16702
作者:
Song, Zilan
;
Liu, Bo
;
Peng, Xia
;
Gu, Wangting
;
Sun, Yiming
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2022/06/15
The double faced role of xanthine oxidoreductase in cancer
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Chen, Man-Man
;
Meng, Ling-Hua
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/01/04
xanthine oxidoreductase (XOR)
ROS
uric acid
cancer therapy
Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities