中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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  • 上海药物研究所 [23]
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发表日期
  • 2023 [23]
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浏览/检索结果: 共23条，第1-10条 帮助

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Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua
  |  收藏  |  浏览/下载：6/0  |  提交时间：2024/02/19
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects 期刊论文  OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:  Yang, Xin-Mei;  Yang, Yang;  Yao, Bu-Fan;  Ye, Pan-Pan;  Xu, Yan
  |  收藏  |  浏览/下载：11/0  |  提交时间：2023/12/11
Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933
作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu
  |  收藏  |  浏览/下载：8/0  |  提交时间：2024/01/26
The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology 期刊论文  OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 17
作者:  Wang, Yu-Jun;  Zan, Gui-Ying;  Xu, Cenglin;  Li, Xue-Ping;  Shu, Xuelian
  |  收藏  |  浏览/下载：14/0  |  提交时间：2024/02/19
A novel branched galacturonan from Gardenia jasminoides alleviates liver fibrosis linked to TLR4/NF-kappa B signaling 期刊论文  OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 卷号: 245, 页码: 14
作者:  Ma, Xiaonan;  Zhou, Wanqi;  Nie, Yingmin;  Jing, Xiaoqi;  Li, Saijuan
  |  收藏  |  浏览/下载：10/0  |  提交时间：2023/10/17
DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of Rev1 and Polq in mouse embryonic stem cells 期刊论文  OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 30, 页码: 11
作者:  Jiang, Fangjie;  Wang, Lin;  Dong, Yuping;  Nie, Wenhui;  Zhou, Hu
  |  收藏  |  浏览/下载：9/0  |  提交时间：2023/12/08
Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells 期刊论文  OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 页码: 11
作者:  Cai, Haiyan;  Wang, Yingying;  Zhang, Jing;  Wei, Zhenquan;  Yan, Teng
  |  收藏  |  浏览/下载：16/0  |  提交时间：2023/10/17
Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma 期刊论文  OAI收割
NATIONAL SCIENCE REVIEW, 2023, 卷号: 10, 期号: 8, 页码: 17
作者:  Zhu, Hongwen;  Lin, Youpei;  Lu, Dayun;  Wang, Shisheng;  Liu, Yuejia
  |  收藏  |  浏览/下载：23/0  |  提交时间：2023/10/17
Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 11
作者:  Wang, Han-lin;  Li, Jia-nan;  Kan, Wei-juan;  Xu, Gao-ya;  Luo, Guang-hao
  |  收藏  |  浏览/下载：20/0  |  提交时间：2023/10/17
Stimuli-activatable PROTACs for precise protein degradation and cancer therapy 期刊论文  OAI收割
SCIENCE BULLETIN, 2023, 卷号: 68, 期号: 10, 页码: 1069-1085
作者:  Gao, Jing;  Yang, Lei;  Lei, Shumin;  Zhou, Feng;  Nie, Huijun
  |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17