中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [44]
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Discovery of GPX4 inhibitors through FP-based high-throughput screening
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14
作者:
Cao, Yu
;
Wu, Bin
;
Xu, Ying
;
Wang, Mingchen
;
Wu, Xinyu
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/02/27
GPX4 inhibitor
HTS assay
Ferroptosis
Fluorescence polarization
Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study
期刊论文
OAI收割
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12
作者:
Zhao, Tian-Tian
;
Hu, Hao-Jie
;
Gao, Li-Xin
;
Zhou, Yu-Bo
;
Zhu, Yun-Long
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Protein tyrosine phosphatases inhibitors
PTP1B inhibitors
Mechanism study
Molecular dynamics
Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer
期刊论文
OAI收割
ADVANCED SCIENCE, 2023, 卷号: 10, 期号: 17
作者:
Zhu, Hongwen
;
Yu, Hua
;
Zhou, Hu
;
Zhu, Wencheng
;
Wang, Xiongjun
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/27
cMyc
CXCL1
IL8
liver cancer
neutrophil
nuclear PHGDH
Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 卷号: 226, 页码: 780-792
作者:
Xiang, Yusen
;
Zhai, Guanglei
;
Li, Yaozong
;
Wang, Mengge
;
Chen, Xixiang
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/04/10
SARS-CoV-2
S-RBD
Ginkgolic acid
Editorial: Pharmacokinetics of herbal medicines and herb-drug interactions
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 3
作者:
Jia, Wei-Wei
;
Lu, Chuang
;
Lin, Ge
;
Ge, Guang-Bo
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/04/10
herbal medicine
pharmacokinetics
drug combination
drug interaction
molecular mechanism
drug transporter
drug-metabolizing enzyme
Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2022, 页码: 11
作者:
Zhou, Liping
;
Liu, Tingting
;
Mo, Mengxia
;
Shi, Yulong
;
Wu, Leyun
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/11/11
Simultaneous determination of almonertinib and its active metabolite HAS-719 in human plasma by LC-MS/MS: Evaluation of pharmacokinetic interactions
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2022, 卷号: 1197, 页码: 7
作者:
Liu, Lu
;
Yang, Le
;
Li, Wei
;
Chen, Xiaoyan
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/08/16
Almonertinib
LC -MS
MS
Active metabolite (HAS-719)
Pharmacokinetic drug-drug interaction
Discovery of PHGDH inhibitors by virtual screening and preliminary structure-activity relationship study
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2022, 卷号: 121, 页码: 13
作者:
Zhang, Fu-Mao
;
Yuan, Liang
;
Shi, Xin-Wei
;
Feng, Kai-Rui
;
Lan, Xiaojing
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/06/15
Virtual screening
PHGDH
Structure-activity relationships
Antitumor
Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 3, 页码: 1523-1533
作者:
Wu, Canhao
;
Xu, Qin
;
Wang, Huiyuan
;
Tu, Bin
;
Zeng, Jiaxin
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/06/15
SARS-CoV-2
COVID-19
Spike protein
Pseudovirus
Extracellular vesicles
ACE2
Intranasal administration
Neutralization
Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin
期刊论文
OAI收割
GLYCOCONJUGATE JOURNAL, 2021, 页码: 11
作者:
Zeng, Jiaxin
;
Meng, Yuan
;
Chen, Shi-Yi
;
Zhao, Gaofeng
;
Wang, Lianchun
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2021/12/01
Furin
Heparan sulfate
Heparin
Virus infection
Carbohydrate-protein interaction