中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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西北高原生物研究... [102]
上海药物研究所 [47]
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期刊论文 [341]
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Discovery of GPX4 inhibitors through FP-based high-throughput screening
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14
作者:
Cao, Yu
;
Wu, Bin
;
Xu, Ying
;
Wang, Mingchen
;
Wu, Xinyu
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/02/27
GPX4 inhibitor
HTS assay
Ferroptosis
Fluorescence polarization
Enhanced NIR-II Fluorescent Lateral Flow Biosensing Platform Based on Supramolecular Host-Guest Self-Assembly for Point-of-Care Testing of Tumor Biomarkers
期刊论文
OAI收割
ACS APPLIED MATERIALS & INTERFACES, 2023, 页码: 13
作者:
Song, Zhaorui
;
Guo, Hong
;
Suo, Yongkuan
;
Zhang, Yongde
;
Zhang, Shanshan
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/19
point-of-care testing
rare-earth nanoparticles
NIR-II fluorescence
host-guest self-assembly
tumor biomarkers
Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF)
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 12
作者:
Wu, Xinyu
;
Wang, Mingchen
;
Cao, Yu
;
Xu, Ying
;
Yang, Ziqun
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/02/27
O-GlcNAcylation
O-GlcNAc transferase
High-throughput screening
Inhibitor
Spectral and biodistributional engineering of deep near-infrared chromophore
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 9, 页码: 7
作者:
Dong, Yan
;
Lu, Xicun
;
Li, Yi
;
Chen, Weichao
;
Yin, Lei
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
Near infrared fluorophore
In vivo imaging
Molecular engineering
Biological distribution
Angiography
Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 91, 页码: 11
作者:
Zhao, Yitian
;
Zhang, Min
;
Hou, Xudong
;
Han, Jiaxin
;
Qin, Xiaoya
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Salicylanilide
hPL inhibitor
Structure -activity relationship
Anti -obesity
Ratiometric sensing of beta-galactosidase based on excited-state intramolecular proton transfer (ESIPT) and solid-state luminescence enhancement
期刊论文
OAI收割
ORGANIC CHEMISTRY FRONTIERS, 2023, 卷号: 10, 期号: 12, 页码: 2913-2917
作者:
Tian Jr, He
;
Lin, Wei
;
Hu, Xi-Le
;
Wang, Jing-Bo
;
Zhang, Min-Yu
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/10/17
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
期刊论文
OAI收割
THORACIC CANCER, 2022
作者:
Xu, Chunwei
;
Si, Lu
;
Wang, Wenxian
;
Li, Ziming
;
Song, Zhengbo
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/12/22
fusion
precision medicine
solid tumor
targeted therapy
tyrosine receptor kinase
DeepBindBC: A practical deep learning method for identifying native-like protein-ligand complexes in virtual screening
期刊论文
OAI收割
METHODS, 2022, 卷号: 205, 页码: 247-262
作者:
Zhang, Haiping
;
Zhang, Tingting
;
Saravanan, Konda Mani
;
Liao, Linbu
;
Wu, Hao
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/07/12
Native like protein-ligand
Drug virtual screening
ResNet
Deep learning
Human pancreatic alpha amylase inhibitor
Recent progress in assays for GPCR drug discovery
期刊论文
OAI收割
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022, 卷号: 323, 期号: 2, 页码: C583-C594
作者:
Guo, Shimeng
;
Zhao, Tingting
;
Yun, Ying
;
Xie, Xin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/04/10
biased signaling
GPCR
high -throughput screening assays
humanized mouse model
protein
protein interaction
Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 237, 页码: 13
作者:
Zhao, Jiannan
;
Li, Yongling
;
Ma, Jing
;
Liu, Jingting
;
Xiao, Ruoxuan
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/08/16
NLRP3
Inflammasome
Inhibitor
Fluorescence imaging
Sulfonylurea