中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [24]
水生生物研究所 [2]
上海生物化学与细胞生... [2]
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大连化学物理研究所 [1]
昆明植物研究所 [1]
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OAI收割 [33]
内容类型
期刊论文 [33]
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2022 [7]
2021 [4]
2020 [5]
2019 [2]
2018 [8]
2016 [4]
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Biochemist... [1]
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Molecular recognition of morphine and fentanyl by the human mu-opioid receptor
期刊论文
OAI收割
CELL, 2022, 卷号: 185, 期号: 23, 页码: 4361-+
作者:
Zhuang, Youwen
;
Wang, Yue
;
He, Bingqing
;
He, Xinheng
;
Zhou, X. Edward
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/04/10
PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way
期刊论文
OAI收割
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 卷号: 10, 期号: 10, 页码: 15
作者:
Yu, Xiaolu
;
Long, Yiru
;
Chen, Binfan
;
Tong, Yongliang
;
Shan, Mengwen
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2022/12/13
PD-L1
TLR7
nanobody-drug-conjugate
cancer immunotherapy
Effects of low-dose bisphenol AF on mammal testis development via complex mechanisms: alterations are detectable in both infancy and adulthood
期刊论文
OAI收割
ARCHIVES OF TOXICOLOGY, 2022, 期号: 0, 页码: 1-11
作者:
Li, Yuanyuan
;
Xiong, Yiming
;
Lv, Lin
;
Li, Xinghong
;
Qin, Zhanfen
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2022/11/08
MANUFACTURING PLANT
EXPOSURE
ESTROGEN
DIETHYLSTILBESTROL
ANALOGS
RATS
EXPRESSION
PROTEIN
HEALTH
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
Darbalaei, Sanaz
;
Chang, Ru-lue
;
Zhou, Qing-tong
;
Chen, Yan
;
Dai, An-tao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/09/30
glucagon-like peptide-1 receptor
glucagon receptor
dual and triple agonist
cAMP
pERK1/2
unimolecular polypharmacology
Recent progress in assays for GPCR drug discovery
期刊论文
OAI收割
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022, 卷号: 323, 期号: 2, 页码: C583-C594
作者:
Guo, Shimeng
;
Zhao, Tingting
;
Yun, Ying
;
Xie, Xin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/04/10
biased signaling
GPCR
high -throughput screening assays
humanized mouse model
protein
protein interaction
Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 20, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Qingtong
;
Li, Yang
;
Chen, Li-Nan
;
Zhang, Zi-Chen
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/09/30
glucagon-like peptide-1 receptor
type 2 diabetes mellitus
cryoelectron microscopy
peptidomimetic agonism
Farnesoid X receptor (FXR) agonists induce hepatocellular apoptosis and impair hepatic functions via FXR/SHP pathway
期刊论文
OAI收割
ARCHIVES OF TOXICOLOGY, 2022, 页码: 15
作者:
Zhang, Tianwei
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/06/15
FXR agonist
Hepatotoxicity
Farnesoid X receptor
Obeticholic acid
Px-102
Apoptosis
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1
期刊论文
OAI收割
NATURE CHEMICAL BIOLOGY, 2021, 页码: 24
作者:
Shao, Zhehua
;
Shen, Qingya
;
Yao, Bingpeng
;
Mao, Chunyou
;
Chen, Li-Nan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/06/15
Constitutive signal bias mediated by the human GHRHR splice variant 1
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Fulai
;
Zhang, Chao
;
Zou, Xinyu
;
Zhang, Huibing
  |  
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2021/12/01
class B1 GPCR
receptor bias
cancer
cell proliferation
Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 192, 页码: 16
作者:
Yuliantie, Elita
;
van der Velden, Wijnand J. C.
;
Labroska, Viktorija
;
Dai, Antao
;
Zhao, Fenghui
  |  
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2021/11/04
Glucose-dependent insulinotropic polypeptide receptor
G protein-coupled receptor
GPCR structure-function relationship
ERK
cAMP
Arrestin