机构

• 上海药物研究所 [22]
• 成都生物研究所 [3]
• 上海营养与健康研究所 [2]
• 大连化学物理研究所 [1]
• 昆明植物研究所 [1]
• 上海有机化学研究所 [1]
• 更多

采集方式

• OAI收割 [35]

内容类型

• 期刊论文 [33]
• 学位论文 [2]

发表日期

• 2024 [1]
• 2023 [1]
• 2022 [1]
• 2021 [5]
• 2020 [3]
• 2019 [2]
• 更多

学科主题

• Biochemist... [1]
• Cell Biolo... [1]
• Endocrinol... [1]
• Oncology [1]
• Science & ... [1]
• 天然产物研究 [1]
• 更多

筛选

浏览/检索结果: 共35条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   SH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade 期刊论文  OAI收割 ARTHRITIS & RHEUMATOLOGY, 2022, 页码: 12 作者:  Liu, Qianqian;  Zhai, Linhui;  Han, Mingrui;  Shi, Dongquan;  Sun, Ziying   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/06/15 Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13 作者:  Meng, Xiang-Dong;  Gao, Li-Xin;  Wang, Zhi-Jia;  Feng, Bo;  Zhang, Chun   |  收藏  |  浏览/下载：62/0  |  提交时间：2021/12/01 2,5-diphenyl-1,3,4-oxadiazole derivatives  SHP2  Inhibitors  Structure-activity relationships (SAR)   A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies 期刊论文  OAI收割 MOLECULAR CELL, 2021, 卷号: 81, 期号: 19, 页码: 4076-+ 作者:  Liu, Zhiwei;  Liu, Yingluo;  Qian, Lili;  Jiang, Shangwen;  Gai, Xiameng   |  收藏  |  浏览/下载：60/0  |  提交时间：2021/12/01 Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1) 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105 作者:  Yu Lijie;  Feng Bo;  Wang Zhijia;  Gao Lixin;  Zhang Chun   |  收藏  |  浏览/下载：95/0  |  提交时间：2021/11/04 5-phenyl-1,3,4-thiadiazole derivatives  Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)  inhibitors  structure-activity relationships   Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14 作者:  Yang, Xiangbo;  Wang, Zhijia;  Pei, Yuan;  Song, Ning;  Xu, Lei   |  收藏  |  浏览/下载：29/0  |  提交时间：2021/08/17 SHP2 degradation  Proteolysis targeting chimera (PROTAC)  Thalidomide-based heterobifunctional molecules  E3 ubiquitin ligase  CRBN   Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020) 期刊论文  OAI收割 CURRENT MEDICINAL CHEMISTRY, 2021, 卷号: 28, 期号: 19, 页码: 3825-3842 作者:  Wu, Jingwei;  Zhang, Huan;  Zhao, Guilong;  Wang, Runling   |  收藏  |  浏览/下载：15/0  |  提交时间：2021/08/17 SHP2 inhibitor  PTPN11 gene  allosteric  cancer  combination therapy  clinical trial   Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856 作者:  Liu, Wen;  Yin, Ye;  Wang, Meijing;  Fan, Ting;  Zhu, Yuyu   |  收藏  |  浏览/下载：86/0  |  提交时间：2020/12/24 Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)  hepatic steatosis  insulin resistance  caspase-1  interleukin 18 (IL-18)  fatty liver  metabolic disorder  inflammation  cytokine signaling  caspase 1 (CASP1)  tyrosine-protein phosphatase (tyrosine phosphatase)  macrophage   Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5 作者:  Satheeshkumar, Rajendran;  Zhu, Rui;  Feng, Bo;  Huang, Chao;  Gao, Ya   |  收藏  |  浏览/下载：38/0  |  提交时间：2020/07/01 Heterocyclic bis-aryl amides  PTP1B  SHP2  Inhibitors  Structure-activity relationships (SAR)