中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [13]
国家天文台 [3]
光电技术研究所 [3]
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水生生物研究所 [2]
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期刊论文 [34]
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2025 [1]
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Communicat... [1]
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Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Song, Pei-ran
;
Wan, Zhi-peng
;
Huang, Ge-ge
;
Song, Zi-lan
;
Zhang, Tao
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2024/07/12
diffuse large B-cell lymphoma
BTK inhibitors
drug resistance
BTK C481F
BTK A428D
SYHA1813
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
期刊论文
OAI收割
EMBO MOLECULAR MEDICINE, 2023, 页码: 24
作者:
Wang, Li-Min
;
Wang, Pingyuan
;
Chen, Xiao-Min
;
Yang, Hui
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2023/04/10
homologous recombination repair
olaparib-resistant
PARP inhibitor
PARP7
type I interferons
Ultrahigh temperature metamorphism and isobaric cooling of Neoarchean ultramafic-mafic granulites in the southern granulite terrain, India: Phase equilibrium modelling and SHRIMP zircon U-Pb dating
期刊论文
OAI收割
JOURNAL OF METAMORPHIC GEOLOGY, 2022, 页码: 31
作者:
Gou, Long-Long
;
Zhai, Ming-Guo
;
Zhang, Cheng-Li
;
George, Paul Mathews
;
Lu, Jun-Sheng
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/07/05
garnet pyroxenite
lower crust
mafic granulite
phase equilibrium modelling
Southern Granulite Terrain
Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS(G12C) inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 213, 页码: 17
作者:
Xiao, Xuanzheng
;
Lai, Mengzhen
;
Song, Zilan
;
Geng, Meiyu
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2021/05/24
KRAS
Covalent inhibitor
Pyridopyrimidinone
Antiproliferative effect
Scaffold hopping
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yu-ting
;
Ding, Hui-hua
;
Lin, Ze-min
;
Wang, Que
;
Chen, Li
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/05/24
rheumatoid arthritis
BTK inhibitors
B cells
macrophages
RANKL
osteoclastogenesis
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
期刊论文
OAI收割
AUTOPHAGY, 2021, 卷号: 17
作者:
Klionsky, Daniel J.
;
Abdel-Aziz, Amal Kamal
;
Abdelfatah, Sara
;
Abdellatif, Mahmoud
;
Abdoli, Asghar
  |  
收藏
  |  
浏览/下载:319/0
  |  
提交时间:2021/05/31
Autophagosome
cancer
flux
LC3
lysosome
macroautophagy
neurodegeneration
phagophore
stress
vacuole
Synthesis and Biological Evaluation of Oxopyrido[2,3-d] Pyrimidine-7-ones Derivatives as Covalent L85812/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors
期刊论文
OAI收割
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 8, 页码: 826-834
作者:
Niu, Ao
;
Wang, Yang
;
Yang, Yushe
;
Wei, Jianhai
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer
irreversible inhibitors
EGFR(T79014)( )mutant
anti-tumor
xenograft model
cell proliferation
The MALATANG Survey: The LGAS–LIR Correlation on Sub-kiloparsec Scale in Six Nearby Star-forming Galaxies as Traced by HCN J?=?4?→?3 and HCO+ J?=?4?→?3
期刊论文
OAI收割
The Astrophysical Journal, 2018, 卷号: 860, 期号: 2
作者:
Tan,Qing-Hua
;
Gao,Yu
;
Zhang,Zhi-Yu
;
Greve,Thomas R.
;
Jiang,Xue-Jian
  |  
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2019/05/23
galaxies: ISM
galaxies: star formation
infrared: galaxies
ISM: molecules
radio lines: galaxies
The MALATANG Survey: The LGAS–LIR Correlation on Sub-kiloparsec Scale in Six Nearby Star-forming Galaxies as Traced by HCN J?=?4?→?3 and HCO+ J?=?4?→?3
期刊论文
OAI收割
The Astrophysical Journal, 2018, 卷号: 860, 期号: 2
作者:
Tan,Qing-Hua
;
Gao,Yu
;
Zhang,Zhi-Yu
;
Greve,Thomas R.
;
Jiang,Xue-Jian
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/03/11
galaxies: ISM
galaxies: star formation
infrared: galaxies
ISM: molecules
radio lines: galaxies