中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [92]
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期刊论文 [272]
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Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Sesquiterpene lactones from
Tithonia diversifolia
with ferroptosis-inducing activities
期刊论文
OAI收割
PHYTOCHEMISTRY, 2024, 卷号: 226, 页码: 12
作者:
Ding, Ao-Xue
;
Shan, Yi -Ming
;
Li, Chen-Yue
;
Qin, Guo -Qing
;
Chen, Tong
  |  
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2024/08/22
Tithonia diversifolia
Asteraceae
Sesquiterpene lactones
Ferroptosis
Cytotoxic effects
The Pivotal Role of Heavy Terpenes and Anthropogenic Interactions in New Particle Formation on the Southeastern Qinghai-Tibet Plateau
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2024
作者:
Liu, Yuliang
;
Nie, Wei
;
Qi, Ximeng
;
Li, Yuanyuan
;
Xu, Tao
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/11/20
new particle formation
highly oxygenated organic molecules
Qinghai-Tibet Plateau
sesquiterpenes
diterpenes
NOx-influenced chemistry
biogenic-anthropogenic interactions
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1, 页码: 17
作者:
Zhang, Tao
;
Pan, Zilu
;
Gao, Jing
;
Wu, Qingqing
;
Bai, Gang
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/10/21
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Song, Pei-ran
;
Wan, Zhi-peng
;
Huang, Ge-ge
;
Song, Zi-lan
;
Zhang, Tao
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2024/07/12
diffuse large B-cell lymphoma
BTK inhibitors
drug resistance
BTK C481F
BTK A428D
SYHA1813
Cross-ancestry genome-wide association studies of brain imaging phenotypes
期刊论文
OAI收割
NATURE GENETICS, 2024, 页码: 31
作者:
Fu, Jilian
;
Zhang, Quan
;
Wang, Jianhua
;
Wang, Meiyun
;
Zhang, Bing
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/06/29
Eighteen iridoids from the roots and rhizomes of
Valeriana
jatamansi
and their protective effects against α-hemolysin
期刊论文
OAI收割
PHYTOCHEMISTRY, 2024, 卷号: 219, 页码: 10
作者:
Zhu, Yao
;
Guo, Peng-Ju
;
Ding, Ao-Xue
;
Zheng, Liu
;
Du, Gao-Xiang
  |  
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2024/03/25
Valeriana jatamansi Jones
Iridoids
alpha-hemolysin
Protective effects
A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy
期刊论文
OAI收割
CANCER COMMUNICATIONS, 2024, 页码: 5
作者:
Liu, Yingqiang
;
Tong, Linjiang
;
Zhang, Mengge
;
Zhang, Qi
;
Liu, Qiupei
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2024/03/13
Preliminary Results of the Seismicity Monitoring Experiment around the 2019
M
w5.4 Earthquake Epicenter in the Central South China Sea Basin
期刊论文
OAI收割
JOURNAL OF EARTH SCIENCE, 2024, 卷号: 35, 期号: 1, 页码: 212-220
作者:
Gong, Wenfei
;
Ruan, Aiguo
;
Niu, Xiongwei
;
Wang, Zhenjie
;
Tan, Pingchuan
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2024/04/07
South China Sea
microseismic monitoring
earthquakes
fault
broadband OBS
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
;
Zhan, Zhengsheng
;
Kang, Zhuang
;
Li, Mengyuan
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably